Multi-Organ Multi-Omics Computational Framework to Understand Iron Disorders
Official title: Developing a Multi-Organ Multi-Omics Computational Framework for StudyingMammalian Iron Systems Biology
Funded at Jackson Laboratory · NIH-11393875 · Data updated 2026-11-12
A research project is turning big-picture data about iron levels in blood and tissues into insights that could help people with iron-related illnesses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | August 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $486,750 |
| NIH project number | 5R35GM160386-02 |
| Project ID | NIH-11393875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with iron deficiency, iron deficiency anemia, iron overload, or related iron metabolism disorders may benefit from future advances stemming from this research.
✕Less likely to help
People without iron metabolism disorders are unlikely to directly benefit from this study.
What this research studies
This program at The Jackson Laboratory will build a new computational framework called MOMO-seq to study how iron moves through the body and causes disorders. It will integrate data from multiple organs and molecular layers to map how iron metabolism goes wrong in conditions like iron deficiency and iron overload. By focusing on the root biological causes, the work aims to pave the way for personalized approaches to diagnosis and treatment. The research is designed to translate basic biology into strategies that could improve care for patients with iron-related diseases over the next five years.
Why it matters
Potential benefit: If successful, the project could lead to personalized interventions for iron disorders and better therapeutic strategies.
How similar studies have gone: Prior research shows that integrative, multi-omics approaches can reveal mechanisms behind iron biology, but this project aims to advance these methods further for clinical relevance.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Agoro, Rafiou — Jackson Laboratory
- Study coordinator: Agoro, Rafiou
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.