Single-cell long-read sequencing to map cancer RNA variants
Official title: Advancing and Validating Single-Cell Long-Read Sequencing for Broad Adoption in Cancer Molecular Profiling
Funded at Jackson Laboratory · NIH-11428903 · Data updated 2026-11-12
A cancer research grant aims to make advanced single-cell RNA sequencing more accurate and widely usable to understand how different RNA isoforms affect brain and breast cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $452,458 |
| NIH project number | 1R33CA315144-01 |
| Project ID | NIH-11428903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with brain cancer or breast cancer who are undergoing tumor sampling or research collaborations could participate in future validation studies.
✕Less likely to help
No direct patient benefit until the tools are validated and translated into clinical assays.
What this research studies
This grant plans to develop and test improved single-cell long-read sequencing tools to map full-length RNA transcripts in tumors. It focuses on how alternative splicing shapes cancer cell behavior and drug responses, with the goal of linking splicing patterns to tumor heterogeneity. The work will validate methods that can capture diverse isoforms at single-cell resolution, making precision cancer profiling more accessible and actionable for patients.
Why it matters
Potential benefit: If successful, patients could benefit from more precise RNA-based tumor profiling that informs targeted therapies and better prediction of treatment responses.
How similar studies have gone: Existing single-cell RNA sequencing methods show promise, but this project aims to overcome current limitations with long-read approaches for full-length isoform detection.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Anczukow-Camarda, Olga — Jackson Laboratory
- Study coordinator: Anczukow-Camarda, Olga
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.