Molecular mapping of human gene function through multi-omic profiling
Official title: Multi-omic phenotyping of human transcriptional regulators
Funded at Jackson Laboratory · NIH-11397574 · Data updated 2026-11-12
A program is testing how turning off or reducing specific human genes changes cells over time using advanced sequencing and other lab methods.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 11, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $545,877 |
| NIH project number | 5U01HG013175-04 |
| Project ID | NIH-11397574 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient participation in this grant; the work is laboratory-based and uses cell models.
✕Less likely to help
No direct patient involvement or treatment is expected in this grant.
What this research studies
This project uses CRISPR-based gene knockouts and degron techniques to temporarily or permanently suppress transcription factors and other genes in human cells. Researchers will profile molecular changes over time with bulk and single-cell RNA sequencing, ATAC-seq, and other data to understand how gene perturbations alter cell states. The goal is to build a reliable catalog of gene functions by measuring variability in perturbations and sequencing signals across many conditions. The work will integrate data from multiple centers and compare with existing functional genomics resources to strengthen conclusions.
Why it matters
Potential benefit: This research could illuminate how genes control cell behavior, potentially guiding future therapies that target gene function.
How similar studies have gone: Previous studies using CRISPR perturbations and multi-omics have shown that gene function can be mapped at scale, though integrating multi-modal data remains challenging.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: White, Brian S — Jackson Laboratory
- Study coordinator: White, Brian S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.