Mouse resources and validation core for addiction genetics models
Official title: Mouse Resources and Validation Core
Funded at Jackson Laboratory · NIH-11389626 · Data updated 2026-11-12
A center at The Jackson Laboratory helps create and validate mouse models to study addiction, using special mouse populations and CRISPR to generate and share new disease-relevant strains.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | August 15, 2016 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $310,023 |
| NIH project number | 5P50DA039841-10 |
| Project ID | NIH-11389626 on NIH RePORTER |
Who could benefit from this research
✓Could help
No direct patient participation is required; this is a research resource to support studies that may ultimately impact patients with addiction.
✕Less likely to help
There is no direct patient participation or immediate treatment for individuals in this core facility.
What this research studies
The Mouse Resources and Validation Core (MRVC) provides centralized mouse production and model development for the Center for Systems Neurogenetics of Addiction. It uses specialized mouse populations like Collaborative Cross and Diversity Outbred, along with a large repository of strains, to validate candidate genes. The core will generate genetically engineered mouse models and cell lines using CRISPR/Cas9 and then store and distribute these models for ongoing research on addiction. This work supports in vivo validation and expanded phenotyping to advance understanding of how genetic variants influence addiction-related behaviors. The MRVC also serves as a shared resource to streamline collaboration across CSNA projects.
Why it matters
Potential benefit: If successful, patients could benefit from faster translation of genetic findings into better animal models that guide therapies for addiction.
How similar studies have gone: Similar mouse-resource centers and CRISPR-based model creation have accelerated validation of candidate genes in addiction research.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Reinholdt, Laura G — Jackson Laboratory
- Study coordinator: Reinholdt, Laura G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.