Knockout Mouse Project to map human-relevant genes and disease links
Official title: The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2)
Funded at Jackson Laboratory · NIH-11386540 · Data updated 2026-11-12
A project at The Jackson Laboratory plans to create and thoroughly study 600 engineered mouse lines to help understand how human genes work and how they relate to disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 16, 2011 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,392,254 |
| NIH project number | 5UM1OD023222-15 |
| Project ID | NIH-11386540 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient participation in this grant, but findings may ultimately impact people with genetic diseases.
✕Less likely to help
The project itself does not recruit patients or provide direct patient interventions.
What this research studies
This program uses CRISPR technology to generate knockout mice for genes with human counterparts that lack good biological data or annotations. The mice will undergo broad phenotyping to build a deeper map of gene functions and potential disease connections. By linking mouse gene function to human biology, researchers aim to inform future drug screening and preclinical studies. The work is built on collaboration with partners to ensure the selected genes have clear relevance to human biology and disease mechanisms.
Why it matters
Potential benefit: If successful, the work could accelerate the identification of new targets for therapies and improve the translation of mouse data to human disease.
How similar studies have gone: Previous knockout and phenotyping efforts have shown that mouse models can illuminate human gene function and disease mechanisms.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Braun, Robert E — Jackson Laboratory
- Study coordinator: Braun, Robert E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.