Improved Reporter Mice to Advance Gene Editing
Official title: Developing Improved Reporter Mouse Models for In Vivo Gene Editing
Funded at Jackson Laboratory · NIH-11356481 · Data updated 2026-11-12
A small research project uses specially designed mice to help scientists test new gene editing tools and understand how they work inside living bodies.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $486,750 |
| NIH project number | 1R21OD040605-01 |
| Project ID | NIH-11356481 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with genetic conditions that could be treated by precise genome editing may benefit indirectly as therapies move toward clinical testing.
✕Less likely to help
Healthy volunteers or individuals without interest in genetic editing research would not directly benefit from this project.
What this research studies
This project will develop and test new mouse models that glow or report when gene editing occurs, helping researchers measure where and when edits happen and how efficiently they work. By comparing different editing approaches, the team aims to identify safer and more effective methods for precise genome changes. The work will use established mouse strains, introduce editing tools, and track outcomes with imaging and molecular analyses to guide future therapies. The goal is to strengthen preclinical evidence so that human studies can be designed more confidently.
Why it matters
Potential benefit: If successful, the project could accelerate the development of safer gene editing therapies for people with genetic diseases by providing better preclinical models.
How similar studies have gone: Similar reporter mouse models have been used to optimize gene editing tools and have shown valuable insights in prior work.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Bergstrom, David Eric — Jackson Laboratory
- Study coordinator: Bergstrom, David Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.