Disease models to study autoimmune diseases and test therapies
Official title: Disease Modeling Unit
Funded at Jackson Laboratory · NIH-11393947 · Data updated 2026-11-12
A program to create and test animal models of human autoimmune diseases so researchers can understand disease mechanisms and try new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 1, 2020 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $954,653 |
| NIH project number | 5U54OD030187-07 |
| Project ID | NIH-11393947 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; this grant supports model development that could benefit patients through future therapies.
✕Less likely to help
Patients are not directly recruited for this grant, and immediate clinical benefits are not the focus.
What this research studies
The Disease Modeling Unit at The Jackson Laboratory uses advanced genome editing and comprehensive phenotyping to build and validate complex in vivo models of autoimmune diseases. It emphasizes humanized models, diverse genetic backgrounds, and precise allele design to better reflect human conditions. Researchers access this pipeline and JAX’s tools to guide therapeutic testing in robust, translatable systems.
Why it matters
Potential benefit: If successful, these models could accelerate development of effective therapies for autoimmune diseases by providing better preclinical tests.
How similar studies have gone: Prior work with humanized and allele-specific models has improved translational relevance, showing promise for predicting human responses.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Murray, Stephen a — Jackson Laboratory
- Study coordinator: Murray, Stephen a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.