Spatial patterns of RNA isoforms in aging breast cancer development
Official title: Building a spatial transcriptomics infrastructure for isoform profiling in aging pre-neoplastic tissues
Funded at Jackson Laboratory · NIH-11387511 · Data updated 2026-11-12
A new approach will map where different RNA isoforms appear in aging breast tissue to understand how cancer starts and evolves.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $834,699 |
| NIH project number | 5R33AG080243-04 |
| Project ID | NIH-11387511 on NIH RePORTER |
Who could benefit from this research
✓Could help
People at risk for or diagnosed with breast cancer, especially those concerned about aging-related risk, could benefit from future developments.
✕Less likely to help
Results may not directly benefit individuals if findings do not translate into new tests or therapies within the study period.
What this research studies
This project uses advanced spatial transcriptomics to study breast tissue as it ages, aiming to link age-related changes to cancer initiation. It focuses on full-length RNA isoforms, which may drive tumor development and treatment responses, and seeks to overcome limitations of single-cell methods that miss these isoforms. The work will integrate tissue context with RNA splicing data to create a map of aging-driven changes that could influence breast cancer risk and progression.
Why it matters
Potential benefit: If successful, it could lead to better early detection and personalized treatment strategies for aging-related breast cancer.
How similar studies have gone: Previous studies show that RNA isoforms can influence tumor behavior, but applying spatial isoform profiling to aging-related breast cancer is novel.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Anczukow-Camarda, Olga — Jackson Laboratory
- Study coordinator: Anczukow-Camarda, Olga
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.