Interventions to Slow Aging in Mammals
Official title: Interventions That Retard Mammalian Aging
Funded at Jackson Laboratory · NIH-11362050 · Data updated 2026-11-12
This NIH grant funds studies testing drugs to see if they can extend lifespan and delay age-related diseases in mice, with the goal of informing future human anti-aging therapies.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | April 15, 2003 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,770,000 |
| NIH project number | 5U01AG022308-23 |
| Project ID | NIH-11362050 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults aged 21+ who are interested in participating in future translational studies or who stand to benefit from anti-aging research developments.
✕Less likely to help
People seeking immediate therapeutic options now may not directly benefit from these preclinical mouse studies.
What this research studies
The project runs at three established sites and uses standardized methods to test many drugs across diverse mice, aiming to detect meaningful increases in lifespan. Results from past experiments have highlighted several agents that may influence aging, guiding which compounds to study further. The work is designed to build knowledge that could translate into human health benefits as aging processes are better understood. Participants are not current patients in this stage, but the findings may shape future human trials and therapies for aging-related conditions.
Why it matters
Potential benefit: If successful, the research could identify drugs that slow aging and reduce late-life diseases, potentially informing future human treatments.
How similar studies have gone: Prior experiments within this program have shown longevity effects for several agents, supporting continued exploration of anti-aging interventions.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Korstanje, Ronny — Jackson Laboratory
- Study coordinator: Korstanje, Ronny
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
Biological aging across the lifespan through a national high school-to-adult study
This grant uses a long-running national study of students and adults to collect saliva biomarkers of aging, alongside surveys, to understand how aging markers relate to health and life experiences.
-
Understanding how aging and Alzheimer’s affect how people make tough choices
This NIH grant studies how aging and Alzheimer’s risk change how people decide between immediate and delayed rewards and risky options, with the goal of helping older adults stay financially and healthwise safer.
-
Understanding how brain resilience and multiple brain pathologies influence aging and Alzheimer's disease
A long-term study follows older adults to learn how resilience to brain changes helps reduce dementia risk and what biological factors are linked to better cognitive aging.
-
National Neighborhood Data Archive helps researchers study aging health in U.S. neighborhoods
A nationwide data resource will help researchers understand how where people live affects health and aging, with a focus on respiratory illnesses in older adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.