Sponsor or institution

Clinical trials and research at Case Western Reserve University

• 22Clinical trials
• 661NIH research projects
• 1Country

Newest trials

All recruiting trials (22)

• Support for Just-In-Time Consent for Prenatal Screening

  This study tests a short set of information cards delivered on a phone to help pregnant people decide about prenatal screening.

  Recruiting at 3 sites Case Western Reserve University · San Francisco, California and 2 other locations · NCT07557303

• Humidity and Mold—Healthy Home Interventions for Kids with Asthma

  This study tests whether affordable home humidity control and mold-reduction measures can help reduce asthma symptoms in children with asthma.

  Recruiting Case Western Reserve University · Cleveland, Ohio and 1 other locations · NCT07453667

• Arestin with deep cleaning to improve gums and blood-sugar control in type 2 diabetes

  This trial will test whether adding Arestin (minocycline microspheres) to deep dental cleaning helps close periodontal pockets and improves blood sugar and inflammation in adults with type 2 diabetes and moderate to severe periodontitis.

  Recruiting Early Phase 1 Case Western Reserve University · Cleveland, Ohio · NCT07298057

• Optimizing sensory feedback to maximize hand and arm function after tetraplegia

  This project tests different patterns of brain and nerve electrical stimulation to restore touch and pressure sensations in people with cervical spinal cord injuries who already have ReHAB implants.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT07225582

• Youth Empowerment and Safety program for sexual and gender minority teens

  This project will try Peer Support Specialist (PSS) services to see if they help sexual and gender minority youth ages 12–17 who are involved with juvenile justice, child welfare, or community mental health and who have experienced self-harm or suicidal thoughts.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT07214233

• Long-term comparison of two treatments for tooth decay in older adults

  This project will test whether twice-yearly silver diamine fluoride works as well as atraumatic restorative treatment with fluoride varnish for preventing and treating tooth decay in older adults who participated in a prior housing-based study in Northeast Ohio.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT07213661

• Preventing under-fueling in collegiate athletes with improved nutrition

  This project will try routine nutrition screenings and sports-dietitian support to prevent low energy availability in Division III collegiate athletes at Case Western Reserve University.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT07136038

• Theater and arts program to build resilience and reduce anxiety in children and teens

  This program will test whether adding CBT techniques to theatrical improvisation, improvisation alone, or a social craft group helps reduce anxiety and depression in children and adolescents with elevated symptoms.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT07033052

• Clubhouse-based care for people with schizophrenia and related conditions

  This study tests whether the Clubhouse Model of psychosocial rehabilitation helps thinking skills and daily function more than usual community mental health care in adults with schizophrenia, schizoaffective disorder, or schizophreniform disorders.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT07006935

• Medically tailored groceries to support pregnant people facing food insecurity

  This project will test whether home-delivered medically tailored groceries, with or without extra food education, help Medicaid-eligible pregnant people in Cuyahoga County improve nutrition and birth outcomes.

  Recruiting at 2 sites Case Western Reserve University · Cleveland, Ohio and 1 other locations · NCT06965530

• New psychotherapy for PTSD and depression after sexual assault

  This study is testing a new short therapy session to see if it can help college students who have experienced sexual assault feel better by reducing their PTSD and depression symptoms.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT06900712

• Improving Oral Health for Older Adults in Primary Care

  This study is testing whether better training for doctors and changes to their systems can help older adults on Medicaid get more dental care and improve their oral health.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT06555029

• Analyzing changes in oral microbiome during dental implant placement

  This study looks at how the bacteria in the mouth change when people with severe gum disease get dental implants and whether different implant materials affect these changes.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT06149585

• A program to improve mental health after traumatic events

  This study is testing a new program called PATH to see if it helps people with PTSD and depression feel better after a traumatic event, compared to a relaxation technique called Progressive Muscle Relaxation.

  Recruiting at 3 sites Case Western Reserve University · Newark, Delaware and 2 other locations · NCT06093906

• Comparing immediate and delayed loading of maxillary overdenture implants

  This study is testing whether putting in maxillary overdenture implants right away or waiting three months affects bone loss and other outcomes for patients over three years.

  Recruiting at 2 sites Case Western Reserve University · Cleveland, Ohio and 1 other locations · NCT06038487

• Comparing two methods for treating gum recession on lower front teeth

  This study is testing two different surgical methods for treating gum recession on the lower front teeth to see which one works better.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT06037161

• Using womb sounds to help preterm infants breathe better

  This study tests if playing womb sounds can help preterm infants breathe better by supporting their brain development during a crucial time.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT05298748

• Improving medication adherence and blood pressure control in older African Americans

  This study is testing a new technology-based program to help older African Americans better manage their high blood pressure and improve their overall health.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT05293756

• Using brain stimulation to treat opioid addiction and chronic pain

  This study is testing if a new brain stimulation treatment can help people with opioid addiction and chronic pain feel better compared to a placebo.

  Recruiting at 3 sites Case Western Reserve University · Hinsdale, Illinois and 2 other locations · NCT04379115

• Improving oxygen delivery during blood transfusions with S-nitrosylation therapy

  This study is testing if a special treatment can improve oxygen delivery to tissues during blood transfusions to help people feel better after receiving stored red blood cells.

  Recruiting Phase 1 Case Western Reserve University · Cleveland, Ohio · NCT03999229

• Evaluation of a neuroprosthesis for improving mobility in paralyzed individuals

  This study is testing a new device that helps people with paralysis improve their movement and balance through a special electrical stimulation system implanted in their muscles.

  Recruiting at 2 sites Case Western Reserve University · Cleveland, Ohio and 1 other locations · NCT00623389

• Understanding genetic factors in Barrett's esophagus and esophageal cancer

  This study is trying to find out how genetics play a role in Barrett's esophagus and esophageal cancer to help improve early detection and treatment for patients.

  Recruiting at 10 sites Case Western Reserve University · Baltimore, Maryland and 9 other locations · NCT00288119

NIH-funded research (newest 40 of 661)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Estrogen signaling and how the intestinal lining protects against injury

  A study at Case Western Reserve University looks at how estrogen receptors in the gut lining help protect against intestinal injury and inflammatory bowel disease.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11609166

• Diabetes: Long-term effects of intensive glucose control on complications

  A long-term study follows adults with type 1 diabetes to see how keeping blood sugar close to normal affects eye, kidney, nerve, heart, and quality of life outcomes over many years.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11608534

• Epidemiology of Diabetes Interventions and Complications (EDIC) Study follow-up

  This long-term study follows adults with type 1 diabetes to see how early intensive glucose control affects complications and quality of life over many years.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11608533

• Role of THAP1 in brain cell support cells shaping brain development

  Aims to understand how the THAP1 protein in oligodendrocyte lineage cells helps shape the brain’s environment and myelination during development, which may relate to a movement disorder called DYT6 dystonia.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11596702

• New human monoclonal antibodies to stop malaria caused by Plasmodium vivax

  A researcher team is developing human monoclonal antibodies to prevent and treat malaria from Plasmodium vivax, with a plan to test promising antibodies in primates and prepare for human trials.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11572319

• PopCASE: A user-friendly tool to link cancer data for communities and researchers

  Aimed at improving population cancer research, PopCASE helps connect patient cancer data with community information to inform better care and outreach.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11565336

• Structure-enhanced ML methods for spatial transcriptomics cell type deconvolution

  A bidirectional, smarter way to figure out which cell types are present in tissue pictures from spatial gene expression data, helping brain tumor patients and researchers.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11535833

• Diabetes and Donor Tissue in Corneal Transplants

  This grant studies whether corneas from donors with diabetes affect the success of Descemet membrane endothelial keratoplasty (DMEK) and what factors predict better or worse outcomes.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11531413

• Enhancing MST with MY-SCOPE and machine learning to study in-session communication

  A project to make Multisystemic Therapy more effective for teens with serious behavior problems by using a new tool called MY-SCOPE and machine learning to analyze what happens during therapy sessions.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11523058

• How alternative splicing shapes brain development and its epigenetic programs

  A small NIH-funded project will explore how a brain-specific splice variant of a chromatin regulator helps guide brain cell development.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11484189

• How fine particle air pollution (PM2.5) changes immune metabolism linked to heart disease and type 2 diabetes

  This project explores whether long-term exposure to fine particle air pollution (PM2.5) changes immune and metabolic systems in ways that raise the risk of heart disease and type 2 diabetes in exposed people.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11471379

• HIV latency reversal: unlocking viral reactivation across HIV subtypes

  A researcher-led project aims to uncover new ways to reactivate latent HIV in immune cells so that treatment interruption could be possible for people living with HIV.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11470655

• Mettl3-related RNA changes in Alzheimer's disease

  A scientist-led project will explore how a specific RNA modification (m6A) controlled by METTL3 affects brain aging and Alzheimer's disease in people and models.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11463373

• HIV clinical trials unit serving Cleveland, Cincinnati, and Kampala

  This program runs HIV treatment, vaccine, and related studies for adults living with or at risk for HIV.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11456877

• Using higher glucose to help pancreatic cancer respond to chemotherapy

  This study tests whether increasing glucose around pancreatic tumors can make chemotherapy work better for people with localized pancreatic cancer.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11455430

• Using the brain’s natural connector to detect and prevent seizures

  A study at Case Western Reserve University is exploring whether gently stimulating a natural brain pathway called the corpus callosum can help identify where seizures start and stop them from spreading in people with hard-to-control epilepsy.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11449578

• Glymphatic Waste Clearance in Aging Brain and its Link to Alzheimer’s Disease

  A long-term study will explore how the brain’s waste-clearing system works in aging people at risk for Alzheimer’s disease and what lifestyle changes like exercise might do to help.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11449391

• New ways to prevent rearrest after resuscitation from sudden cardiac arrest

  This grant tests new strategies to prevent rearrest after resuscitation from sudden cardiac arrest in order to improve survival.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11448696

• Understanding how male hormone balance and FGFs shape sperm maturation in 3D lab models

  This project uses a 3D lab model of the human epididymis to study how balancing male hormones (androgens and estrogens) and FGFs affects the development and function of the ducts that help sperm mature.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11447100

• Vitamin A balance: how the body controls absorption and fat metabolism

  Researchers are studying how the body tightly controls vitamin A uptake and fat metabolism by tracking key molecules that act in the gut and liver.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11446182

• Proteolytic PR-B cleavage: a new idea on how progesterone withdrawal starts labor

  A study in pregnant people looks at how a hormone signal may change inside uterine cells to trigger labor, aiming to understand how to prevent preterm birth.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11438541

• Photobiomodulation to Boost CAR-T Cell Therapy for B-Cell Cancers

  A patient-facing overview of using light-based therapy to improve CAR-T cell treatment for B-cell cancers, aiming for better effectiveness and lower costs.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11437508

• A Tablet-Based Emotion Regulation Program for Surrogate Decision-Makers of ICU Patients on Ventilation

  A randomized trial tests a brief tablet program to help people who decide for ICU patients on ventilation feel less anxious and make better decisions.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11431767

• Mechanistic insight into how EphA2 shape controls its activity

  A scientist is studying how a protein called EphA2 changes shape to turn on or off signals related to blood vessel and heart disease, with results that could guide new therapies.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11430262

• Understanding GBP1’s role in fighting infections and protecting cells

  A study at Case Western Reserve University will explore how GBP1, a protein that helps cells defend against infections, works at the molecular level and how it protects our own cells from pathogens.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11427756

• How gut microbes influence our genes and cell fate

  A scientist-led project at Case Western Reserve University studies how microbes living in our gut communicate with our own cells to change how our genes are read and how cells develop.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11424836

• Family Health Risk Tool Using AI and EHR for IPV Survivors

  A patient-friendly tool uses electronic health records and AI to identify health risks for people affected by intimate partner violence and help coordinate care.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11424753

• Exploratory Trial of a modular, networked neurostimulation system to aid people with spinal cord injury

  A personalized, implantable neurostimulation system is being tested to help people with spinal cord injury improve multiple daily functions.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11424035

• Just-in-time consent for prenatal screening in pregnancy

  This project explores whether giving consent for prenatal genetic screening at the moment it’s offered helps patients make informed choices.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11423723

• How cells control arginine methylation on proteins

  This work explores how cells add, remove, and read methyl tags on protein arginine residues, which could help people with cancers driven by these changes.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11423440

• TNFRSF13B gene variants and kidney transplant immune responses

  This NIH grant explores how genetic differences in a single gene may influence antibody responses and graft outcomes after kidney transplantation.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11419629

• Understanding how the brain controls the eye’s surface

  This NIH grant aims to uncover how nerves keep the eye’s surface healthy and comfortable by studying the brain’s control of tear production and blinking.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11419012

• How a dystonia-linked protein affects brain support cells and myelin

  This project looks at how the THAP1 protein linked to DYT6 dystonia changes the behavior of brain support cells and the surrounding matrix, which could affect myelination in adults with DYT-THAP1.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11418173

• Cross-D-domain AI method to predict major cardiovascular events

  A precision AI tool will use transfer learning to predict major cardiovascular events like stroke or heart attack using simple, low-cost screening data.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11417269

• KINDER: A new approach to help family caregivers prevent psychological elder abuse in dementia care

  A study tests a caregiver-focused program designed to reduce psychological abuse by family members caring for someone with Alzheimer’s or related dementias.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11416728

• Circadian disruption and air pollution link to cardiometabolic risk in people with HIV/AIDS

  A long-term study exploring how sleep-wake cycles and circadian disruption interact with air pollution to affect heart and metabolic health in people with HIV/AIDS and related conditions.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11416438

• Targeting PRMT5 to improve treatment for triple-negative breast cancer

  This project seeks to help people with triple-negative breast cancer by blocking a protein called PRMT5 and changing cell 'self-cleaning' (autophagy) so treatments work better.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11416217

• HIV-CRISP: A same-day test-and-switch tool for HIV viral load and drug resistance

  A new at-your-side test uses CRISPR and a microfluidic chip to quickly measure HIV amount and resistance to common drugs during the same clinic visit.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11411739

• Plasma Cell-Free Hemoglobin and Immune Health in HIV

  Aiming to understand whether fragments of red blood cells in the blood of people with HIV affect immune function and blood vessel health.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11411529

• Personalized Metastasis-Directed Therapy for Prostate Cancer with Imaging and Biopsy Boost

  A large North American trial will test whether targeted radiation to metastases helps men with a specific type of prostate cancer and uses biomarker tests and imaging to tailor treatment.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11411288

Quick answers

How many clinical trials run by Case Western Reserve University are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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