TNFRSF13B gene variants and kidney transplant immune responses
Official title: TNFRSF13B polymorphisms and immunity to transplantation
Funded at Case Western Reserve University · NIH-11419629 · Data updated 2026-11-12
This NIH grant explores how genetic differences in a single gene may influence antibody responses and graft outcomes after kidney transplantation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $749,430 |
| NIH project number | 5R01AI173950-05 |
| Project ID | NIH-11419629 on NIH RePORTER |
Who could benefit from this research
✓Could help
Kidney transplant recipients or candidates who are part of the linked cohorts and have available genotype and antibody data.
✕Less likely to help
Patients not enrolled in transplantation programs or lacking genetic/antibody data may not benefit.
What this research studies
Researchers will study TNFRSF13B gene variants to understand how B cells react to transplanted kidneys and how antibodies form against the graft. They will analyze allo-specific B cells from kidney transplant recipients to see how different genotypes affect antibody production, affinity, and timing. The study will combine data from large transplant cohorts (Michigan Genomics Initiative, NIH APOLLO) and validate findings in other major studies (DeKAF and GEN03) to link genetic variation with transplant outcomes. The goal is to reveal mechanisms that could predict rejection risk and guide personalized care for transplant patients.
Why it matters
Potential benefit: If successful, the work could help predict which patients are at higher risk of antibody-mediated rejection and tailor therapies to improve graft survival.
How similar studies have gone: Prior observations linked TNFRSF13B mutations to higher rejection risk, and this project intends to validate and extend those findings in large cohorts.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Cascalho, Marilia Isabel — Case Western Reserve University
- Study coordinator: Cascalho, Marilia Isabel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.