New ways to prevent rearrest after resuscitation from sudden cardiac arrest
Official title: Novel mechanisms and prevention of rearrest during resuscitation
Funded at Case Western Reserve University · NIH-11448696 · Data updated 2026-11-12
This grant tests new strategies to prevent rearrest after resuscitation from sudden cardiac arrest in order to improve survival.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 15, 2018 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $767,655 |
| NIH project number | 2R01HL142754-05A1 |
| Project ID | NIH-11448696 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients at risk of sudden cardiac arrest or those who have survived initial resuscitation could benefit from future translation of these findings.
✕Less likely to help
Current patients not connected to the resuscitation workflow or not experiencing rearrest may not benefit.
What this research studies
If someone experiences a sudden cardiac arrest, the next phase often sees rearrest due to ongoing heart rhythm problems. This project uses animal models to explore how keeping heart cell connections intact and stabilizing calcium and sodium balance might prevent rearrest. It also tests a machine learning approach that uses ECG features to predict rearrest so clinicians can tailor treatment. The work aims to identify precise steps during resuscitation that reduce the chance of another arrest.
Why it matters
Potential benefit: If successful, the research could lead to new treatments during resuscitation that reduce rearrest and improve survival after cardiac arrest.
How similar studies have gone: Previous work showed machine learning can predict rearrest and that protecting gap junctions may help; this project builds on that evidence in preclinical models.
Where this research is happening
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Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Laurita, Kenneth — Case Western Reserve University
- Study coordinator: Laurita, Kenneth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.