Clinical trial Recruiting at 1 site Interventional Ages 12 to 17

Youth Empowerment and Safety program for sexual and gender minority teens

Official title: Youth Empowerment and Safety Intervention for Systems-involved Sexual and Gender Minority Youth at Risk of Suicide

Run by Case Western Reserve University · NCT07214233 · Data updated 2026-11-12

This project will try Peer Support Specialist (PSS) services to see if they help sexual and gender minority youth ages 12–17 who are involved with juvenile justice, child welfare, or community mental health and who have experienced self-harm or suicidal thoughts.

More Suicide trials

Quick facts

Study typeInterventional
Ages12 Years to 17 Years
SexAll
Enrollment60 (estimated)
SponsorCase Western Reserve University
Academic / other
Locations1 site (Cleveland, Ohio)
StatusRecruiting
StartedFebruary 23, 2026
Main results expectedNovember 30, 2027
Study endsNovember 30, 2027
Registry record updatedMay 8, 2026
Trial IDNCT07214233 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are English-speaking youth ages 12–17 who self-identify as sexual or gender minorities, are involved with juvenile justice, child welfare, or community mental health systems, and have personal experience with self-injurious thoughts or behaviors, along with their willing primary caregivers.

Probably not a fit

Those unlikely to benefit include people outside the 12–17 age range, youth who do not identify as sexual or gender minorities, youth not involved with the listed public systems, individuals without SITB history, non-English speakers, or those unable to provide assent/consent.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Youth Empowerment & Safety (YES) approach combines system-level improvements in identifying and referring self-injurious thoughts and behaviors (SITB) among sexual and gender minority youth (SGMY) with the introduction of SGMY-tailored Peer Support Specialists (PSS). Participants receive either usual services or additional PSS support aimed at improving engagement with behavioral health treatment and other supports. The trial will measure feasibility, acceptability, and initial impact on engagement and safety-related outcomes among 12–17 year olds and their caregivers within public systems. Implementation takes place through partnerships with juvenile justice, child welfare, and community mental health settings at the study site in Cleveland, Ohio.

Why it matters

Potential benefit: If successful, the program could increase engagement in behavioral health services and strengthen supports that reduce risk of self-injury and suicidal crises for SGMY youth.

How similar studies have gone: Peer Support Specialists have been shown in prior work to improve engagement in mental health services, but combining system-level identification/referral with SGMY-tailored PSS for system-involved suicidal youth is a more novel application with limited prior evidence.

Who can join: the full rules

Show full inclusion / exclusion criteria
Child Inclusion Criteria:

* 12-17 years of age
* Self-identify as a sexual or gender minority (SGM)
* Involved in one or more system: juvenile justice, child welfare, and/or community-based mental health
* Personal experience with self-injurious thoughts and behaviors (SITB)
* English speaking
* Willing and able to provide informed assent

Child Exclusion Criteria:

* Less than 12 or greater than 17 years of age (0-11 or 18 and over)
* Do not self-identify as a sexual or gender minority (SGM)
* Not involved in the juvenile justice, child welfare, and/or community-based mental health systems
* No personal experience with self-injurious thoughts and behaviors (SITB)
* Not English speaking
* Unwilling and/or unable to provide informed assent

Caregiver Inclusion Criteria:

* 18-80 years of age
* Primary Caregiver of youth who meet child inclusion criteria listed above
* English speaking
* Willing and able to provide informed consent

Caregiver Exclusion Criteria:

* Less than 18 or greater than 80 years of age (0-17 or 81 and over)
* Not the Primary Caregiver of youth who meet child inclusion criteria listed above
* Not English speaking
* Unwilling and/or unable to provide informed consent

Where it's running

  • Case Western Reserve University
    Cleveland, Ohio, United States
    Recruiting

Study contacts

  • Principal investigator: Dana M. Prince, PhD — Case Western Reserve University
  • Study coordinator: Dana M. Prince, PhD
  • Email: dana.prince@case.edu
  • Phone: 216-368-1707

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Combining the Youth-Nominated Support Team with CBT for Black adolescents at acute suicide risk

    This project will test whether adding a computer-assisted Youth-Nominated Support Team to Cognitive Behavioral Therapy for Suicide Prevention helps Black adolescents (ages 12-17) who come to an urban emergency setting with suicidal thoughts or self-injury.

    Recruiting at 2 sites University of Michigan · Detroit, Michigan and 1 other locations · NCT07506460

  • Examining skills and coping in teens' daily lives

    This study is testing two different skills to see which helps teens who have hurt themselves feel better and cope with stress in their daily lives.

    Recruiting University of Utah · Salt Lake City, Utah · NCT06720753

  • Understanding the impact of mood disorders and treatment responses

    This study is trying to learn more about how people with depression and bipolar disorder respond to treatment by talking to them weekly for up to 12 weeks to improve future care and predict how well medications might work.

    Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06462196

  • Friends and family training for those at risk of suicide

    A six-week program tests whether training for caregivers can help them support a loved one at risk of suicide while also taking care of their own mental health.

    Recruiting Unity Health Toronto · Toronto, Ontario · NCT07902089

  • Inhaled DMT for major depressive disorder

    This trial tests whether inhaled DMT can quickly ease depressive symptoms and reduce suicide risk in adults with major depressive disorder.

    Recruiting Phase 2 Universidade Federal do Rio Grande do Norte · Fortaleza, Ceará and 4 other locations · NCT07562191

  • Suicide risk and learned suicide ability in people with mood disorders

    This project will try to identify which biological, psychological, social, and clinical factors relate to suicide risk and the learned ability for suicide in people aged 16–60 with mood disorders by collecting blood, urine, and questionnaire data.

    Recruiting Tianjin Anding Hospital · Tianjin, Tianjin Municipality · NCT07523490

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.