Diabetes: Long-term effects of intensive glucose control on complications
Official title: Epidemiology of Diabetes Interventions and Complications (EDIC) Study
Funded at Case Western Reserve University · NIH-11608534 · Data updated 2026-11-12
A long-term study follows adults with type 1 diabetes to see how keeping blood sugar close to normal affects eye, kidney, nerve, heart, and quality of life outcomes over many years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 22, 2011 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $106,665 |
| NIH project number | 3U01DK094157-16S1 |
| Project ID | NIH-11608534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 1 diabetes who were part of the original DCCT/EDIC cohorts and are willing to participate in ongoing follow-up.
✕Less likely to help
Individuals without a history of type 1 diabetes or those not enrolled in long-term observational follow-up would not directly benefit.
What this research studies
This project continues the EDIC observational follow-up of the DCCT cohort to understand how early gains from intensive glucose control influence future health in adults with type 1 diabetes. Researchers collect standardized data on complications, cardiovascular risk factors, neurocognition, and quality of life, building on past results that showed lasting benefits beyond initial glycemic differences. The study helps explain why early intensive therapy may have lasting effects, including the concept of metabolic memory. Participation involves long-term follow-up visits and data collection to track health outcomes over time.
Why it matters
Potential benefit: If successful, the findings could guide long-term diabetes management to reduce complications and improve life quality.
How similar studies have gone: Edic has already demonstrated lasting benefits of early intensive therapy; this continues to clarify long-term impact.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Gubitosi-Klug, Rose a — Case Western Reserve University
- Study coordinator: Gubitosi-Klug, Rose a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.