Mettl3-related RNA changes in Alzheimer's disease
Official title: Role of Mettl3-dependent RNA m6A dysregulation in Alzheimer's disease
Funded at Case Western Reserve University · NIH-11463373 · Data updated 2026-11-12
A scientist-led project will explore how a specific RNA modification (m6A) controlled by METTL3 affects brain aging and Alzheimer's disease in people and models.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $700,897 |
| NIH project number | 4R01AG083811-02 |
| Project ID | NIH-11463373 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with or at risk for Alzheimer's disease and age-related cognitive decline, plus access to relevant brain or cellular samples.
✕Less likely to help
Participants not directly involved in sample collection or who do not have AD-related conditions may not benefit from this study.
What this research studies
This research asks how changes in RNA chemistry inside brain cells contribute to Alzheimer’s disease, linking genetic and environmental factors to brain function. Researchers will study METTL3-dependent m6A modifications and how they alter the expression of genes involved in AD, using brain-related models to understand disease mechanisms. The work may involve analyses of human AD-related samples and animal or cellular models to connect RNA regulation with cognitive and synaptic changes. By clarifying these pathways, the study aims to identify targets that could be used for future therapies or biomarkers.
Why it matters
Potential benefit: It could uncover new molecular targets or biomarkers to slow, prevent, or better diagnose Alzheimer's disease.
How similar studies have gone: Previous work indicates METTL3-m6A dysregulation is linked to cognitive deficits, supporting potential relevance to AD; this study builds on those findings.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Zhu, Xiongwei — Case Western Reserve University
- Study coordinator: Zhu, Xiongwei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.