Understanding genetic factors in Barrett's esophagus and esophageal cancer
Official title: Genetic and Environmental Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
Run by Case Western Reserve University · NCT00288119 · Data updated 2026-11-12
This study is trying to find out how genetics play a role in Barrett's esophagus and esophageal cancer to help improve early detection and treatment for patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Case Western Reserve University Academic / other |
| Locations | 10 sites (Baltimore, Maryland and 9 other locations) |
| Status | Recruiting |
| Started | October 1, 2005 |
| Main results expected | July 31, 2028 |
| Study ends | July 31, 2028 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT00288119 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with Barrett's esophagus or esophageal adenocarcinoma, as well as their family members.
✕Probably not a fit
Patients without a diagnosis of Barrett's esophagus or esophageal adenocarcinoma, or those who do not have family members affected by these conditions, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to explore the genetic and biological factors contributing to Barrett's esophagus and esophageal adenocarcinoma. By utilizing advanced techniques such as balloon capsule sampling and standard endoscopy, the study seeks to collect biospecimens for genetic analysis. The ultimate goal is to enhance early detection, prevention, and treatment strategies for esophageal cancer. The research will also foster collaboration among multiple institutions to improve scientific understanding and translational research in this area.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for early detection and prevention of esophageal cancer, potentially saving lives.
How similar studies have gone: Previous studies using similar genetic and biospecimen collection approaches have shown promise, indicating potential for success in this research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Eligible cases will be defined as those patients and their family members who meet the following criteria: * Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus. * Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent. * Ability to give informed consent, if patient is age 18 or older.
Where it's running
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Johns Hopkins Hospital
Baltimore, Maryland, United States Recruiting -
Mayo Clinic
Rochester, Minnesota, United States Recruiting -
Washington University School of Medicine
St Louis, Missouri, United States Recruiting -
Columbia University Medical Center
New York, New York, United States Recruiting -
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States Recruiting -
University Hospitals of Cleveland
Cleveland, Ohio, United States Recruiting
Show 4 more locations
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Cleveland Clinic
Cleveland, Ohio, United States Recruiting -
University of Pennsylvania
Philadelphia, Pennsylvania, United States Recruiting -
VA Puget Sound Health Care System
Seattle, Washington, United States Recruiting -
Fred Hutchinson Cancer Research Center, UWMC
Seattle, Washington, United States Recruiting
Study contacts
- Principal investigator: Amitabh Chak, MD — University Hospitals Cleveland Medical Center, CWRU, Cleveland, OH
- Study coordinator: Amitabh Chak, MD
- Email: axc22@po.cwru.edu
- Phone: 216-844-5385
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using a capsule system to detect Barrett's Esophagus
This study is testing a new capsule system to see if it can help find Barrett's Esophagus in adults who have had an endoscopy recently.
-
Using tissue, brush, and blood tests to improve cancer risk prediction and quality of life tracking in Barrett's Esophagus
This will try extra biopsies, esophageal brushings, blood tests, and short questionnaires to see if they can better predict cancer risk and track quality of life for adults with Barrett's Esophagus who are being evaluated for possible early cancer.
-
Using a new bipolar knife for removing esophageal lesions
This study is testing a new type of tool for safely removing esophageal growths in patients with precancerous lesions to see if it works better than older methods.
-
Investigating the best biopsy methods for Barrett's Esophagus
This study is testing different biopsy methods to see which one works best for finding early signs of Barrett's Esophagus in patients, especially in Asian populations.
-
Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes
This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.
-
Testing a new imaging capsule for Barrett's Esophagus
This study is testing a new imaging capsule to see if it can safely and easily take pictures of the esophagus in both healthy people and those with Barrett's Esophagus.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.