Understanding genetic factors in Barrett's esophagus and esophageal cancer
Genetic and Environmental Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
This study is trying to find out how genetics play a role in Barrett's esophagus and esophageal cancer to help improve early detection and treatment for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Case Western Reserve University Academic / other |
| Locations | 10 sites (Baltimore, Maryland and 9 other locations) |
| Trial ID | NCT00288119 on ClinicalTrials.gov |
What this trial studies
This research aims to explore the genetic and biological factors contributing to Barrett's esophagus and esophageal adenocarcinoma. By utilizing advanced techniques such as balloon capsule sampling and standard endoscopy, the study seeks to collect biospecimens for genetic analysis. The ultimate goal is to enhance early detection, prevention, and treatment strategies for esophageal cancer. The research will also foster collaboration among multiple institutions to improve scientific understanding and translational research in this area.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with Barrett's esophagus or esophageal adenocarcinoma, as well as their family members.
Not a fit: Patients without a diagnosis of Barrett's esophagus or esophageal adenocarcinoma, or those who do not have family members affected by these conditions, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for early detection and prevention of esophageal cancer, potentially saving lives.
How similar studies have performed: Previous studies using similar genetic and biospecimen collection approaches have shown promise, indicating potential for success in this research.
Eligibility criteria
Show full inclusion / exclusion criteria
Eligible cases will be defined as those patients and their family members who meet the following criteria: * Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus. * Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent. * Ability to give informed consent, if patient is age 18 or older.
Where this trial is running
Baltimore, Maryland and 9 other locations
- Johns Hopkins Hospital — Baltimore, Maryland, United States (Recruiting)
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
- Washington University School of Medicine — St Louis, Missouri, United States (Recruiting)
- Columbia University Medical Center — New York, New York, United States (Recruiting)
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States (Recruiting)
- University Hospitals of Cleveland — Cleveland, Ohio, United States (Recruiting)
- Cleveland Clinic — Cleveland, Ohio, United States (Recruiting)
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (Recruiting)
- VA Puget Sound Health Care System — Seattle, Washington, United States (Recruiting)
- Fred Hutchinson Cancer Research Center, UWMC — Seattle, Washington, United States (Recruiting)
Study contacts
- Principal investigator: Amitabh Chak, MD — University Hospitals Cleveland Medical Center, CWRU, Cleveland, OH
- Study coordinator: Amitabh Chak, MD
- Email: axc22@po.cwru.edu
- Phone: 216-844-5385
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.