Condition

Testicular Cancer clinical trials and research

• 28Clinical trials
• 7NIH research projects
• 11Countries

Newest Testicular Cancer clinical trials

All recruiting trials (28)

• Primary retroperitoneal lymph node surgery versus chemotherapy for good‑prognosis metastatic testicular cancer

  This study will test whether primary RPLND (surgery) instead of standard chemotherapy leads to fewer side effects and better quality of life for men 18 and older with good‑prognosis metastatic testicular cancer.

  Recruiting Sahlgrenska University Hospital · Gothenburg, Göteborg · NCT07498959

• Sodium thiosulfate to protect hearing during cisplatin therapy in adults with solid tumors

  This study tests Pedmark sodium thiosulfate to see if it reduces hearing loss in adults receiving standard cisplatin chemotherapy.

  Recruiting Phase 1/2 University of Arizona · Tucson, Arizona · NCT07407582

• Navigation program for young cancer survivors

  This project tests an adapted navigation program to help adolescent and young adult cancer survivors get timely care within Kaiser Permanente Southern California.

  Recruiting Kaiser Permanente · Pasadena, California · NCT07406087

• Testing trastuzumab deruxtecan (T‑DxD) for HER2‑positive advanced solid tumors

  This will test whether trastuzumab deruxtecan (T‑DxD) helps adults in the US with HER2‑positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have had prior systemic treatment and have no satisfactory alternative options.

  Recruiting at 18 sites AstraZeneca · Birmingham, Alabama and 17 other locations · NCT07124000

• Testing GV20-0251 for advanced or treatment‑resistant solid tumors

  This study will test whether GV20-0251 is safe and tolerable when given every three weeks to adults with advanced or treatment‑resistant solid tumors such as liver, lung, pancreatic cancer, and melanoma.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan · NCT07106827

• How retroperitoneal lymph node dissection affects urination and sexual function

  This project will see if retroperitoneal lymph node dissection (RPLND) for testicular cancer changes urination, ejaculation, erections, and quality of life in adult men.

  Recruiting Jagiellonian University · Krakow, Malopolska · NCT06954233

• Primary retroperitoneal lymph node dissection for seminoma with limited retroperitoneal lymph node spread

  This trial will try surgery (retroperitoneal lymph node dissection) to treat men with pure seminoma who have one or two small (≤3 cm) retroperitoneal lymph node metastases and normal tumor markers.

  Recruiting Phase 2 Western University, Canada · London, Ontario · NCT06932458

• Low-dose aspirin to prevent venous blood clots during chemotherapy for advanced germ cell (testicular) cancer

  This trial will see if taking one daily low-dose aspirin (81 mg) during cisplatin chemotherapy prevents venous blood clots over six months in adults up to age 70 with high-risk advanced germ cell or testicular cancer.

  Recruiting at 3 sites Phase 2 Wake Forest University Health Sciences · Charlotte, North Carolina and 2 other locations · NCT06866964

• Comparing two surgical techniques for testicular cancer treatment

  This study is testing if a new surgical method for treating testicular cancer can help patients feel less pain and need fewer pain medications after surgery compared to the standard method.

  Recruiting at 2 sites Loma Linda University · Loma Linda, California and 1 other locations · NCT06828185

• Radiation plus tarlatamab for DLL3-expressing tumors

  This trial will test whether giving tarlatamab together with standard palliative or consolidative radiation is safe for adults with DLL3-expressing or DLL3-prevalent tumors such as melanoma, medullary thyroid cancer, sinonasal undifferentiated carcinoma, esthesioneuroblastoma, and bladder cancer.

  Recruiting at 3 sites Phase 1/2 University of Arizona · Gilbert, Arizona and 2 other locations · NCT06814496

• Evaluating surgical outcomes for testicular cancer treatment

  This study is testing different surgical methods for treating testicular cancer to see how well they work and how they affect patients' lives.

  Recruiting at 2 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna and 1 other locations · NCT06806917

• Treatment of rare advanced tumors with a combination of drugs

  This study is testing a new combination of drugs to see if it can help people with rare advanced tumors live longer and feel better.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06684327

• Using brodalumab to treat immune-related side effects from cancer therapy

  This study is testing if brodalumab can help cancer patients who are having immune-related side effects from their immunotherapy treatment feel better.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06673329

• Evaluating microRNAs for diagnosing testicular cancer in small masses.

  This study is testing if certain tiny molecules in the blood can help doctors diagnose testicular cancer in adults who have small testicular masses.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06620016

• Comparing intrathecal morphine and intravenous methadone for pain relief after surgery for testicular cancer

  This study is testing whether pain relief after testicular cancer surgery is better with intrathecal morphine or intravenous methadone to help patients feel more comfortable and use less medication.

  Recruiting at 2 sites Phase 3 Indiana University · Indianapolis, Indiana and 1 other locations · NCT06593665

• Evaluating CTIM-76 for patients with recurring ovarian and other advanced cancers

  This study is testing a new treatment called CTIM-76 to see if it can help people with hard-to-treat ovarian and other advanced cancers feel better and live longer.

  Recruiting at 11 sites Phase 1 Context Therapeutics Inc. · Little Rock, Arkansas and 15 other locations · NCT06515613

• Understanding the quality of life and outcomes for testicular cancer patients

  This study is trying to understand how testicular cancer affects patients' quality of life and well-being over time to help improve their care and treatment.

  Recruiting IRCCS San Raffaele · Milan, Lombardy · NCT06389409

• Helping adolescent and young adult cancer survivors manage symptoms and stay engaged in post-treatment care

  This trial will test whether AYA STEPS, a six-session digital program, can help adolescent and young adult cancer survivors reduce symptoms and keep up with recommended follow-up care.

  Recruiting Duke University · Durham, North Carolina · NCT06371768

• Digital peer support for young adults with cancer

  This study is testing a digital support program to see if it can help young adults who have finished cancer treatment by connecting them with trained peers for guidance and encouragement.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06193369

• Investigating cognitive impairment in young cancer patients during and after chemotherapy

  This study is testing how chemotherapy affects memory and attention in children and young adults with cancer to better understand their cognitive challenges during and after treatment.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05840575

• Biobehavioral intervention for young adult testicular cancer survivors

  This study is testing a new therapy to help young adult testicular cancer survivors manage their emotions and stress better, comparing it to regular supportive listening over eight weeks.

  Recruiting University of California, Irvine · Irvine, California · NCT05836688

• Home-based follow-up for testicular cancer patients

  This study tests if a home-based follow-up for people who have recently finished treatment for testicular cancer can help them feel better and less anxious compared to regular hospital visits.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT05670938

• Investigating heart disease in testicular cancer survivors

  This study is testing if testicular cancer survivors who had certain treatments are at higher risk for heart disease, using blood tests and imaging to find early signs of problems.

  Recruiting Indiana University · Indianapolis, Indiana · NCT05611307

• Observational analysis of silicone gel-filled testicular implants

  This study is trying to see how well silicone gel-filled testicular implants work and how satisfied patients are after getting them, for people who need these implants due to various medical conditions.

  Recruiting University Hospital, Ghent · Ghent, East-Flanders · NCT05097820

• Investigating early ageing in young cancer patients during treatment

  This study is trying to see how cancer treatment affects early aging and heart health in young adults aged 18-39 who are undergoing therapy for cancer.

  Recruiting University Medical Center Groningen · Groningen · NCT05062707

• Impact of chemotherapy on early ageing in testicular cancer patients

  This study tests how chemotherapy for testicular cancer affects aging in patients by looking at changes in their skin and fat cells.

  Recruiting University Medical Center Groningen · Groningen · NCT04113122

• AI-based precision oncology clinical trial matching and registry

  This study is testing whether an AI tool can help match cancer patients with the right clinical trials based on their specific cancer details to see if it improves their chances of getting into trials and their overall outcomes.

  Recruiting at 68 sites Massive Bio, Inc. · Birmingham, Alabama and 67 other locations · NCT03452774

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Biobehavioral support to improve life after testicular cancer in young adults

  A youth-focused program helps young men who have survived testicular cancer manage emotions, goals, and health changes after treatment to reduce distress and long-term problems.

  NIH research University of California-Irvine · Irvine, United States · NIH-11345757

• Support to reduce long-term emotional, thinking, and work problems after testicular cancer for young adults

  This project looks at how a therapy called Goal-focused Emotion-Regulation Therapy (GET) and stress-related biology relate to mental health, thinking, and work life in young adults who are long-term survivors of testicular cancer.

  NIH research University of California-Irvine · Irvine, United States · NIH-11338695

• Recreating early testicular cancer precursors in the lab

  They will grow patient-derived germ cells in lab models to recreate the early precursors of adult testicular cancer for young men at risk.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11314558

• Helping Young Adults with Testicular Cancer Thrive After Treatment

  This project offers support to young adults who have completed testicular cancer treatment, helping them manage lasting challenges and achieve their life goals.

  NIH research University of California-Irvine · Irvine, United States · NIH-11128809

• Investigating how cannabinoids may increase the risk of testicular cancer.

  This study is looking into how exposure to cannabis during pregnancy might affect the development of testicular cancer in boys, using lab models to see how substances like THC and CBD could impact the growth of important cells in the testicles.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11089391

• Creating lab models of testicular cancer precursors using stem cells.

  This study is exploring how testicular cancer starts by creating lab models using special cells from patients, which will help researchers learn more about the disease and find better ways to treat it.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11062715

• Helping young adult testicular cancer survivors manage their health and emotions

  This study is testing a supportive program designed to help young adult testicular cancer survivors feel better both physically and emotionally as they adjust back to everyday life after treatment.

  NIH research University of California-Irvine · Irvine, United States · NIH-10881967

Related topics

Quick answers

How many Testicular Cancer clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (14 trials), Italy (3 trials), Netherlands (3 trials), China (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 2: 3, Phase 1/2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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