Creating lab models of testicular cancer precursors using stem cells.
Reconstituting human testicular germ cell neoplasia in situ (GCNIS) in vitro using iPSC-derived primordial germ cell-like cells (PGCLCs) and genetically engineered human testicular cancer cells
This study is exploring how testicular cancer starts by creating lab models using special cells from patients, which will help researchers learn more about the disease and find better ways to treat it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11062715 on NIH RePORTER |
What this research studies
This research aims to better understand testicular cancer by creating in vitro models that mimic the early stages of cancer development from primordial germ cells. Researchers will use induced pluripotent stem cells (iPSCs) from testicular cancer patients to generate primordial germ cell-like cells (PGCLCs). These cells will be genetically modified to reflect the genetic changes associated with Germ Cell Neoplasia In Situ (GCNIS), which are precursors to testicular cancer. By studying these models, the research seeks to uncover the mechanisms behind testicular cancer development and improve future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adult men with a history of testicular cancer or those at high risk for developing it.
Not a fit: Patients with testicular cancer who are already undergoing treatment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for testicular cancer.
How similar studies have performed: While there has been progress in understanding germ cell biology, this approach to modeling GCNIS in vitro is relatively novel and has not been extensively tested.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Shioda, Toshihiro — Massachusetts General Hospital
- Study coordinator: Shioda, Toshihiro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.