Investigating heart disease in testicular cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on late subclinical cardiovascular disease in testicular cancer survivors who have undergone cisplatin-based chemotherapy and/or bone marrow transplant. It aims to evaluate the risk of atherosclerotic cardiovascular disease (ASCVD) in these patients, particularly those diagnosed with testicular cancer at a young age. The study will assess ASCVD risk through blood lipid biomarkers and advanced cardiac CT imaging, comparing three groups of survivors based on their treatment history. The goal is to identify early signs of cardiovascular issues to implement preventive measures.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Patients \>18 years of age
* Patients will be recruited only if cancer-free at clinical evaluation time.
* For the cases a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies (CBCT group, Arm 2)
* For the cases with a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies and underwent BMT for relapsed refractory disease (CBCT \& BMT group, Arm 3).
* For the comparison cohort, biopsy-proven TC patients who had surgery for or surveillance of their testicular cancer and never received CBCTCBCT or BMT (surgical/surveillance, Arm 1)

Exclusion Criteria

* Prior known myocardial infarction (MI), atherosclerotic cardiovascular disease (ASCVD)
* Significant renal disease (GFR\<40)
* Allergy to iodinated contrast
* Antecedent chemotherapy for another primary cancer.

Where it's running

• Indiana University
  Indianapolis, Indiana, United States Recruiting

Study contacts

• Principal investigator: Noah Richardson, MD — Indiana University
• Study coordinator: Elizabeth Rowe
• Email: rowee@iu.edu
• Phone: 317-278-1185

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.