Investigating how cannabinoids may increase the risk of testicular cancer.
Cannabinoids as an environmental risk factor of testicular cancer: Assessment using cell culture models of human and mouse primordial germ cells and by exposure of pregnant mice
This study is looking into how exposure to cannabis during pregnancy might affect the development of testicular cancer in boys, using lab models to see how substances like THC and CBD could impact the growth of important cells in the testicles.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11089391 on NIH RePORTER |
What this research studies
This research explores the potential link between cannabinoid exposure, particularly during pregnancy, and the development of testicular cancer in males. By using cell culture models of human and mouse primordial germ cells, the study aims to understand how cannabinoids like THC and CBD may disrupt normal germ cell development. The researchers will assess the effects of these substances on germ cells and testicular somatic cells to uncover the mechanisms behind any observed cancer risk. This work is crucial for understanding environmental factors that may contribute to testicular cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include young men aged 15 to 44, particularly those with a family history of testicular cancer or those concerned about environmental risk factors.
Not a fit: Patients who are not male or who do not fall within the age range of 15 to 44 years may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for testicular cancer linked to cannabinoid exposure.
How similar studies have performed: Previous epidemiological studies have indicated a significant link between marijuana use and increased testicular cancer risk, suggesting that this research builds on established findings.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Shioda, Toshihiro — Massachusetts General Hospital
- Study coordinator: Shioda, Toshihiro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.