Condition

Sleep-Disordered Breathing clinical trials and research

• 15Clinical trials
• 25NIH research projects
• 1New in 30 days
• 5Countries

Newest Sleep-Disordered Breathing clinical trials

All recruiting trials (15)

• Respiratory progression in adults with Duchenne muscular dystrophy: a long-term observational study

  This study tests how respiratory function changes over three years in adults with genetically confirmed Duchenne muscular dystrophy.

  Recruiting at 13 sites Istituto Giannina Gaslini · Bologna and 12 other locations · NCT07879989

• Tonsillectomy Added to Hypoglossal Nerve Stimulation for OSA with Lateral Wall Collapse

  In adults with obstructive sleep apnea and side-wide airway collapse, this study tests whether adding tonsil removal to hypoglossal nerve stimulation helps more than hypoglossal nerve stimulation alone.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07724938

• Combined upper-airway electrical stimulation with a drug combo for sleep apnea

  This study tests whether adding a drug mix called AtoOxy to an existing hypoglossal nerve stimulation device helps people with sleep apnea sleep better.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT07577661

• Central Sleep Apnea in Heart Failure: How Mechanisms May Guide Treatment

  This study tests whether combining positive airway pressure with a medication (trazodone) or oxygen can reduce central sleep apnea in Veterans with heart failure and ensure better breathing during sleep.

  Recruiting Phase 4 VA Office of Research and Development · Detroit, Michigan · NCT07210606

• Comparing two methods to help children with sleep apnea

  This study is testing whether a special mouth device can help children with sleep apnea sleep better compared to just using nasal care before their surgery.

  Recruiting Université de Montréal · Montreal, Quebec · NCT06634264

• Comparing pain control methods after tonsil surgery in children

  This study is testing whether long-lasting pain medicine like methadone works better than short-lasting options like fentanyl and hydromorphone for controlling pain in kids and teens after tonsil surgery.

  Recruiting Phase 4 Duke University · Durham, North Carolina · NCT06576830

• Observational study on a new wearable device for diagnosing sleep breathing issues in children

  This study is testing a new wearable device to see if it can help doctors better diagnose breathing problems during sleep in children, especially those who find traditional tests hard to use.

  Recruiting NHS Greater Clyde and Glasgow · Glasgow, Glasgow City and 1 other locations · NCT06292299

• Examining the impact of sleep disordered breathing on heart health during pregnancy

  This study looks at how breathing problems during sleep can affect heart health in pregnant people and whether staying active can help protect their hearts.

  Recruiting University of Alberta · Edmonton, Alberta · NCT05908591

• Home initiation of breathing support for children with complex medical needs

  This study is testing if starting breathing support at home for children with complex medical needs is safe and effective compared to starting it in the hospital.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05881031

• Understanding the genetics and immune response in PFAPA syndrome and tonsil disorders

  This study is trying to understand the genetics and immune responses in people with PFAPA syndrome and tonsil problems by collecting and analyzing blood and other samples.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 2 other locations · NCT05656365

• Investigating treatments for sleep apnea in veterans using opioids

  This study is testing whether certain treatments can help veterans with sleep apnea who use opioids breathe better and improve their quality of life.

  Recruiting Phase 1/2 VA Office of Research and Development · Detroit, Michigan · NCT05589753

• Comparing outcomes of lateral pharyngoplasty with tonsillectomy in children

  This study tests if adding a throat surgery called lateral pharyngoplasty to tonsil removal helps children recover better and feel less pain after their operation.

  Recruiting Loma Linda University · Murrieta, California and 3 other locations · NCT05575401

• Understanding long-term effects of breathing patterns in preterm infants

  This study looks at how breathing problems in preterm babies might affect their chances of developing asthma, sleep issues, and learning difficulties as they grow up.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT05336890

• Comparing cardiovascular events in stroke patients with and without sleep-disordered breathing

  This study is trying to see if having sleep-disordered breathing affects the risk of heart and brain problems in stroke patients over the next year.

  Recruiting University Hospital, Grenoble · Grenoble · NCT04399200

• Exploring treatments for central sleep apnea

  This study is testing new combination treatments for central sleep apnea in veterans to see if they can help improve breathing and quality of life.

  Recruiting Phase 4 VA Office of Research and Development · Detroit, Michigan · NCT04118387

NIH-funded research (25)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding and targeting negative effort dependence in sleep apnea

  A doctor-scientist team is studying how breathing effort changes within breaths in sleep apnea to find better ways to prevent airway collapse.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11566570

• Night-to-night sleep-disordered breathing differences in women and men

  A study to find better biomarkers for sleep apnea severity, especially in women, by monitoring people at home for a week and tracking daily mood and energy.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419262

• Serotonin-containing brain cells that help breathing when opioids are used

  Aims to understand how certain brain serotonin cells can reduce opioid-related sleep breathing problems while keeping pain relief.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11415650

• Sleep factors in obesity and diabetes linked to dementia risk in Look AHEAD participants

  This study looks at how sleep problems and daily activity rhythms relate to the risk of Alzheimer’s disease and related dementias in adults with obesity and type 2 diabetes who were part of the Look AHEAD trial.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11402202

• Melanocortin-4 receptor drugs to help sleep apnea in obesity

  A study tests MC4R-activating drugs to help people with obesity-related sleep-disordered breathing who struggle with current treatments.

  NIH research George Washington University · Washington, United States · NIH-11385373

• Serotonin brain circuits to support breathing during opioids and sleep problems

  This grant investigates how specific serotonin-producing brain cells can help keep breathing and airway muscles working when people take opioids and have sleep-disordered breathing, without affecting pain relief.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11312050

• Sleep disorders in veterans with spinal cord injury or disease

  A nationwide VA study will look at how common sleep-disordered breathing is in veterans with spinal cord injury or disease and how it relates to sleep, cognition, and heart health.

  NIH research John D Dingell VA Medical Center · Detroit, United States · NIH-11299603

• Determinants of breathing instability and sleep problems in people on long-term opioids

  A five-year study at UCSD will look at why breathing and sleep become unstable in people who need opioids for long-term pain management.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11295296

• Understanding how sleep apnea treatment changes outcomes in kids using a brain imaging approach

  This grant aims to learn how removing the tonsils and adenoids affects sleep and behavior in children with sleep disordered breathing by watching brain activity patterns.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11291803

• Sleep apnea and its possible effect on multiple myeloma

  This work looks at whether treating sleep apnea can help adults with newly diagnosed multiple myeloma respond better to therapy.

  NIH research University of Iowa · Iowa City, United States · NIH-11235924

• Night-to-night changes in obstructive sleep apnea symptoms in men and women

  The team will track breathing during sleep at home and daytime symptoms over several nights to find clearer signs of obstructive sleep apnea for men and women, including differences by menopausal status.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11195084

• Sleep-related breathing problems in people taking opioid medicines

  This project looks at how sleep-related breathing problems affect people who take chronic opioid medications and tests ways to improve their breathing and health.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11126882

• Investigating how breathing control during sleep can reduce breathing problems linked to opioid use.

  This study is looking at how long-term use of prescription painkillers called opioids can affect your breathing while you sleep, especially if you have issues like sleep apnea, and it aims to find ways to help improve your breathing with treatments like extra oxygen or a specific medication.

  NIH research John D Dingell VA Medical Center · Detroit, United States · NIH-11090322

• Improving blood pressure and vascular function in older adults with sleep-disordered breathing through muscle training.

  This study is testing a quick and easy breathing exercise that takes just 5 minutes a day for six weeks to see if it can help lower blood pressure and improve heart health in older adults with sleep apnea.

  NIH research University of Arizona · Tucson, United States · NIH-11081806

• Understanding how sleep problems in children can be treated effectively

  This study is looking at how surgery to remove tonsils and adenoids can help children with sleep problems that affect their behavior and school performance, and it aims to find out which kids will benefit the most from the surgery.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11037889

• Serotonin brain cells to reduce opioid-related sleep breathing problems

  This work explores whether activating a specific serotonin-producing brain cell type can protect people who take opioids from dangerous breathing problems during sleep.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11016105

• Investigating how sleep apnea affects blood cancer treatment outcomes

  This study is looking at how sleep apnea might affect people with multiple myeloma, a type of blood cancer, and whether using a CPAP machine to treat sleep apnea can help improve their cancer treatment results.

  NIH research University of Iowa · Iowa City, United States · NIH-11011344

• Developing a new tool to diagnose obstructive sleep apnea using advanced technology

  This study is testing a new tool to help doctors easily and accurately diagnose obstructive sleep apnea, especially for people in areas where healthcare is hard to access, so they can get the right treatment faster.

  NIH research Powell Mansfield, INC. · San Diego, United States · NIH-11008902

• Investigating how sleep-disordered breathing varies at night and its effects on men and women.

  This study is looking at how sleep apnea can change from night to night and how it affects men and women differently, especially since women often don’t get diagnosed as often; if you join, you'll use special sleep monitors at home for a week and share how you feel during the day to help find better ways to diagnose an

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10991215

• How low oxygen levels at night affect blood sugar during sleep in people living at high altitudes

  This study is looking at how low oxygen levels while you sleep might affect blood sugar control for people with sleep problems, especially those living at high altitudes, and it will also see if using extra oxygen at night can help improve blood sugar levels.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10916237

• Understanding the genetic causes of sleep disordered breathing

  This study is looking into how our genes might play a role in sleep disordered breathing, a common issue for older adults, to help find better ways to diagnose and treat it.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10895554

• Understanding breathing problems during sleep in opioid users

  This study is looking at how sleep problems related to breathing affect people who are taking opioid medications, and it aims to find better ways to help them sleep and breathe easier at night.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10875430

• Sleep breathing problems and daily activity rhythms linked to dementia risk in people with type 2 diabetes

  This work looks at whether sleep-disordered breathing and disrupted daily activity rhythms are tied to memory loss and Alzheimer's risk in older adults with overweight or type 2 diabetes.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10843942

• Investigating sleep problems in infants with a severe birth defect called myelomeningocele

  This study is looking at how sleep problems affect babies with myelomeningocele, a serious type of spina bifida, to see if better sleep can help their brain development and overall health.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10754237

• A device that automatically adjusts to treat sleep breathing problems.

  This study is testing a new, smart mouthpiece that automatically adjusts to help people with Sleep Disordered Breathing sleep better, making it easier and more comfortable to use than traditional treatments like CPAP.

  NIH research Rush River Research Corporation · Ellsworth, United States · NIH-10697976

Related topics

Quick answers

How many Sleep-Disordered Breathing clinical trials are recruiting right now?

15, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (9 trials), Canada (3 trials), France (1 trial), United Kingdom (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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