Understanding the genetic causes of sleep disordered breathing
Official title: Pathway-level transcriptional causal mechanism of sleep disordered breathing
Funded at Brigham and Women's Hospital · NIH-10895554 · Data updated 2026-11-12
This study is looking into how our genes might play a role in sleep disordered breathing, a common issue for older adults, to help find better ways to diagnose and treat it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $132,047 |
| NIH project number | 5R21HL165324-02 |
| Project ID | NIH-10895554 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing symptoms of sleep disordered breathing.
✕Less likely to help
Patients without sleep disordered breathing or those who are not older adults may not benefit from this research.
What this research studies
This research investigates the genetic and molecular mechanisms behind sleep disordered breathing (SDB), a condition affecting many older adults. By analyzing genetic data and pathway activities, the study aims to identify how specific genes contribute to SDB and its associated health risks. The approach involves using advanced statistical methods to assess the relationships between genetic variations and SDB, potentially leading to the discovery of biomarkers and new treatment targets. Patients may benefit from insights that could improve diagnosis and management of SDB.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from sleep disordered breathing.
How similar studies have gone: Previous research has shown promise in understanding complex diseases through genetic pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Wang, Heming — Brigham and Women's Hospital
- Study coordinator: Wang, Heming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.