Exploring treatments for central sleep apnea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the physiological mechanisms underlying central sleep apnea (CSA) to inform future treatment strategies. It focuses on testing combination therapies, including positive airway pressure (PAP) alongside pharmacological agents like acetazolamide and zolpidem, in veterans with CSA. The goal is to identify effective multi-modality therapies that can normalize respiration and improve the quality of life for patients suffering from this condition. The study aims to provide insights that could guide future clinical trials and enhance care for individuals with CSA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women Veterans with central sleep apnea, defined as Apnea Hypopnea Index (AHI)\>15/hour with CAHI\>5/hour, will be included in the experiments

Exclusion Criteria:

* less than 18 years old
* pregnant or breastfeeding female
* have severe respiratory disease that require to be on oxygen
* recent health event that may affect the ability to participate in the study,
* Body Mass Index (BMI) is \>40 kg/m2
* significant insomnia
* mental instability
* recent health event that may affect sleep
* if at any time the principal investigator (PI) identifies that a certain drug is not suitable, or are unable to use the device that is used to treat sleep apnea, will be not be allowed to participate in the study

Where it's running

• John D. Dingell VA Medical Center, Detroit, MI
  Detroit, Michigan, United States Recruiting

Study contacts

• Principal investigator: M Safwan Badr, MD — John D. Dingell VA Medical Center, Detroit, MI
• Study coordinator: M S Badr, MD
• Email: sbadr@med.wayne.edu
• Phone: (313) 576-1000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Combined upper-airway electrical stimulation with a drug combo for sleep apnea

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.