Sleep apnea and its possible effect on multiple myeloma
Sleep Disordered Breathing as a Targetable Risk Factor in Multiple Myeloma
This work looks at whether treating sleep apnea can help adults with newly diagnosed multiple myeloma respond better to therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11235924 on NIH RePORTER |
What this research studies
You would have your sleep monitored overnight to see if low oxygen during sleep (chronic intermittent hypoxia) is present. Researchers would collect small bone marrow samples to measure immune cells called tumor-associated macrophages and examine their gene activity. If you use CPAP for sleep apnea, the team will compare how those cells change with treatment and follow your response to standard myeloma therapy. The goal is to learn whether fixing sleep breathing problems can improve the chance of remission.
Who could benefit from this research
Good fit: Adults (21+) with newly diagnosed multiple myeloma who are willing to undergo sleep testing and bone marrow sampling are the most appropriate candidates.
Not a fit: People without sleep-disordered breathing, those not willing to use CPAP, or those unwilling to have bone marrow testing may not directly benefit from this project.
Why it matters
Potential benefit: If successful, treating sleep apnea could improve chemotherapy response and increase the likelihood of complete remission in multiple myeloma patients.
How similar studies have performed: Laboratory and animal studies suggest intermittent low oxygen at night alters bone marrow immune cells, but clinical evidence that CPAP improves multiple myeloma outcomes is limited and this is a relatively new clinical direction.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Tomasson, Michael H — University of Iowa
- Study coordinator: Tomasson, Michael H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.