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Fontan clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Fontan clinical trials that are recruiting, at sites in 6 countries (most in United States (2), Hong Kong (1), Germany (1)). By phase: Phase 4 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 6Countries
Newest Fontan clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Dapagliflozin to Improve Exercise and Heart Function in Fontan Patients | Phase 4 | Hong Kong and 1 other locations | Recruiting | Mar 19, 2026 |
| Cholate clearance testing for adults with Fontan circulation or right-sided heart failure | — | Philadelphia, Pennsylvania | Recruiting | Jun 6, 2025 |
| Evaluating the effectiveness of SGLT2 inhibitors in adults with congenital heart disease | — | Baltimore, Maryland and 10 other locations | Recruiting | Apr 17, 2025 |
All recruiting trials (3)
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Dapagliflozin to Improve Exercise and Heart Function in Fontan Patients
This study tests whether the diabetes drug dapagliflozin can improve exercise capacity and heart function in people who had a Fontan procedure.
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Cholate clearance testing for adults with Fontan circulation or right-sided heart failure
This trial will test whether the HepQuant dual cholate clearance blood test can measure liver function in adults with Fontan circulation or right-sided heart failure compared with healthy controls.
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Evaluating the effectiveness of SGLT2 inhibitors in adults with congenital heart disease
This study is trying to see if a new type of diabetes medication can help adults with congenital heart disease feel better and manage their heart failure symptoms.
Related topics
Quick answers
How many Fontan clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 6 countries. The most sites are in United States (2 trials), Hong Kong (1 trial), Germany (1 trial), Netherlands (1 trial), North Macedonia (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.