Investigating blood flow development in children with single ventricle heart disease

Who could benefit from this research

What this research studies

This research focuses on understanding how pulmonary vascular development is affected in children with single ventricle heart disease (SVHD). It aims to measure specific biomarkers in the blood before and after surgical procedures to see how these relate to the development of blood vessels in the lungs. By tracking these changes over time, the study hopes to identify factors that contribute to better or worse outcomes for these children. The approach includes using advanced imaging techniques and blood tests to gather comprehensive data on the patients' health.

Why it matters

Where this research is happening

• University of Colorado Denver
  Aurora, United States Active

Researchers

• Principal investigator: Frank, Benjamin S — University of Colorado Denver
• Study coordinator: Frank, Benjamin S

Related research

Other NIH-funded projects on the same topics.

• Lipid damage and mitochondria: new ways to protect the Fontan heart

  A Stanford-led study aims to find new targets and biomarkers to preserve heart function in children with Fontan circulation by looking at how oxidative stress damages heart cell powerhouses and affects blood vessels.

  NIH research Stanford University · Stanford, United States · NIH-11330408

• Investigating how mitochondrial injury affects blood vessel function in children with congenital heart disease.

  This study is looking at how heart failure affects children who have had a special heart surgery called the Fontan operation, with the goal of finding new ways to spot heart problems early and improve treatments for them.

  NIH research Stanford University · Stanford, United States · NIH-11083653

• Digoxin effects in infants with single‑ventricle heart failure

  This project looks at how the heart drug digoxin behaves and affects newborns and infants who have heart failure from single‑ventricle congenital heart disease.

  NIH research Duke University · Durham, United States · NIH-11045660

• Investigating treatments for single ventricle heart disease

  This study is looking at the special challenges young adults with single ventricle congenital heart disease face as they grow up, and it aims to find better treatments for heart failure that are specific to their needs.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11004040

• Investigating digoxin's effects on infants with heart failure from congenital heart disease

  This study is looking at how the heart medicine digoxin works in babies with heart failure caused by a specific heart condition, hoping to find better ways to help these little ones feel better and live healthier lives.

  NIH research Duke University · Durham, United States · NIH-10807963

• Investigating brain health in children with single ventricle heart disease

  This study is looking at how single ventricle heart disease impacts the brain health of kids and teens, exploring how blood flow and certain brain chemicals might affect their thinking skills, with the goal of finding ways to help them do better in school and everyday life.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10772179

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.