Investigating heart failure in patients with congenital heart disease
Official title: Senescent Cell States in Single Ventricle Disease with Heart Failure
Funded at Texas Heart Institute · NIH-11040756 · Data updated 2026-11-12
This study is looking at Single Ventricle Disease, a serious heart condition, to find out what causes heart failure in people with this disease, and it hopes to create better treatments to help improve heart health for those affected, including patients who may share their samples or information to support the research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Heart Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $655,636 |
| NIH project number | 1R01HL177644-01 |
| Project ID | NIH-11040756 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Single Ventricle Disease, particularly those experiencing heart failure.
✕Less likely to help
Patients with congenital heart disease who do not have Single Ventricle Disease or are not experiencing heart failure may not benefit from this research.
What this research studies
This research focuses on understanding Single Ventricle Disease, a severe form of congenital heart disease that can lead to heart failure in both children and adults. By studying cardiac fibroblasts from patients and animal models, the research aims to uncover the genetic and environmental factors contributing to heart failure in these patients. The goal is to develop new therapies that can improve heart repair and overall outcomes for individuals affected by this condition. Patients may be involved in providing samples or data to help advance this important work.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve heart function and quality of life for patients with congenital heart disease.
How similar studies have gone: Previous research has shown promise in understanding heart failure mechanisms in congenital heart disease, but this specific approach using CRISPR technology and cardiac fibroblasts is relatively novel.
Where this research is happening
-
Texas Heart Institute
Houston, United States Active
Researchers
- Principal investigator: Martin, James F — Texas Heart Institute
- Study coordinator: Martin, James F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.