Investigating treatments for single ventricle heart disease

Who could benefit from this research

What this research studies

This research focuses on understanding the unique challenges faced by patients with single ventricle congenital heart disease as they transition into adulthood. It aims to explore the mechanisms of heart failure specific to this condition, which is often overlooked in traditional heart failure studies. By examining the effects of existing therapies, such as phosphodiesterase-5 inhibitors, the research seeks to identify more effective targeted treatments for these patients. The study will utilize a combination of clinical data and biological samples to better understand the disease and improve patient outcomes.

Why it matters

Where this research is happening

• University of Colorado Denver
  Aurora, United States Active

Researchers

• Principal investigator: Miyamoto, Shelley Deanne — University of Colorado Denver
• Study coordinator: Miyamoto, Shelley Deanne

Related research

Other NIH-funded projects on the same topics.

• Lipid damage and mitochondria: new ways to protect the Fontan heart

  A Stanford-led study aims to find new targets and biomarkers to preserve heart function in children with Fontan circulation by looking at how oxidative stress damages heart cell powerhouses and affects blood vessels.

  NIH research Stanford University · Stanford, United States · NIH-11330408

• Investigating how mitochondrial injury affects blood vessel function in children with congenital heart disease.

  This study is looking at how heart failure affects children who have had a special heart surgery called the Fontan operation, with the goal of finding new ways to spot heart problems early and improve treatments for them.

  NIH research Stanford University · Stanford, United States · NIH-11083653

• Digoxin effects in infants with single‑ventricle heart failure

  This project looks at how the heart drug digoxin behaves and affects newborns and infants who have heart failure from single‑ventricle congenital heart disease.

  NIH research Duke University · Durham, United States · NIH-11045660

• Investigating blood flow development in children with single ventricle heart disease

  This study is looking at how heart surgery affects the growth of blood vessels in the lungs of children with single ventricle heart disease, by checking their blood and using special imaging to help understand what helps them do better or worse after surgery.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11002340

• Investigating digoxin's effects on infants with heart failure from congenital heart disease

  This study is looking at how the heart medicine digoxin works in babies with heart failure caused by a specific heart condition, hoping to find better ways to help these little ones feel better and live healthier lives.

  NIH research Duke University · Durham, United States · NIH-10807963

• Investigating brain health in children with single ventricle heart disease

  This study is looking at how single ventricle heart disease impacts the brain health of kids and teens, exploring how blood flow and certain brain chemicals might affect their thinking skills, with the goal of finding ways to help them do better in school and everyday life.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10772179

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.