Investigating treatments for single ventricle heart disease
Targeting Mitochondria in Single Ventricle Heart Disease
This study is looking at the special challenges young adults with single ventricle congenital heart disease face as they grow up, and it aims to find better treatments for heart failure that are specific to their needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11004040 on NIH RePORTER |
What this research studies
This research focuses on understanding the unique challenges faced by patients with single ventricle congenital heart disease as they transition into adulthood. It aims to explore the mechanisms of heart failure specific to this condition, which is often overlooked in traditional heart failure studies. By examining the effects of existing therapies, such as phosphodiesterase-5 inhibitors, the research seeks to identify more effective targeted treatments for these patients. The study will utilize a combination of clinical data and biological samples to better understand the disease and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with single ventricle congenital heart disease, particularly those transitioning into adulthood.
Not a fit: Patients with other types of congenital heart disease or those without a diagnosis of single ventricle heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatments for patients with single ventricle heart disease, improving their quality of life and longevity.
How similar studies have performed: While there is limited research specifically targeting single ventricle heart disease, similar approaches in other heart conditions have shown promise, indicating potential for success in this area.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Miyamoto, Shelley Deanne — University of Colorado Denver
- Study coordinator: Miyamoto, Shelley Deanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.