Investigating brain health in children with single ventricle heart disease
Brain Metabolites, Brain Antioxidant, and Cerebral Blood Flow Deficits in Single Ventricle Heart Disease
This study is looking at how single ventricle heart disease impacts the brain health of kids and teens, exploring how blood flow and certain brain chemicals might affect their thinking skills, with the goal of finding ways to help them do better in school and everyday life.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10772179 on NIH RePORTER |
What this research studies
This research focuses on understanding how single ventricle heart disease affects brain health in children and adolescents. It examines the relationship between brain metabolites, antioxidant levels, and blood flow to the brain, which may be impaired due to low cardiac output. Using advanced imaging techniques, the study aims to identify changes in brain regions that are crucial for cognitive functions, potentially leading to better management of cognitive deficits associated with this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with single ventricle heart disease.
Not a fit: Patients without single ventricle heart disease or those who are older than 21 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing cognitive function and quality of life in children with single ventricle heart disease.
How similar studies have performed: While the specific approach of this research is novel, there have been other studies indicating the importance of brain health in patients with congenital heart defects.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kumar, Rajesh — University of California Los Angeles
- Study coordinator: Kumar, Rajesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.