Investigating how mitochondrial injury affects blood vessel function in children with congenital heart disease.
Lipid Peroxidation-Induced Mitochondrial Injury Inhibits Vascular Function in Single Ventricle Congenital Heart Disease
This study is looking at how heart failure affects children who have had a special heart surgery called the Fontan operation, with the goal of finding new ways to spot heart problems early and improve treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11083653 on NIH RePORTER |
What this research studies
This research focuses on understanding the unique mechanisms of heart failure in children who have undergone the Fontan operation for single ventricle congenital heart disease. It aims to identify new therapeutic targets and biomarkers that can help detect heart failure earlier in these patients. The study will explore how oxidative stress leads to mitochondrial dysfunction, which may impair blood vessel function both in the heart and throughout the body. By examining the communication between cells in the cardiovascular system, the research seeks to improve treatment options for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have undergone the Fontan operation for single ventricle congenital heart disease.
Not a fit: Patients with heart conditions unrelated to single ventricle congenital heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better preserve heart function and improve outcomes for children with Fontan circulation.
How similar studies have performed: Previous research has indicated that targeting oxidative stress and mitochondrial dysfunction may provide new avenues for treating heart failure, suggesting potential success for this approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Reddy, Sushma — Stanford University
- Study coordinator: Reddy, Sushma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.