Investigating how mitochondrial injury affects blood vessel function in children with congenital heart disease.
Official title: Lipid Peroxidation-Induced Mitochondrial Injury Inhibits Vascular Function in Single Ventricle Congenital Heart Disease
Funded at Stanford University · NIH-11083653 · Data updated 2026-11-12
This study is looking at how heart failure affects children who have had a special heart surgery called the Fontan operation, with the goal of finding new ways to spot heart problems early and improve treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $666,759 |
| NIH project number | 5R01HL165245-03 |
| Project ID | NIH-11083653 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have undergone the Fontan operation for single ventricle congenital heart disease.
✕Less likely to help
Patients with heart conditions unrelated to single ventricle congenital heart disease may not benefit from this research.
What this research studies
This research focuses on understanding the unique mechanisms of heart failure in children who have undergone the Fontan operation for single ventricle congenital heart disease. It aims to identify new therapeutic targets and biomarkers that can help detect heart failure earlier in these patients. The study will explore how oxidative stress leads to mitochondrial dysfunction, which may impair blood vessel function both in the heart and throughout the body. By examining the communication between cells in the cardiovascular system, the research seeks to improve treatment options for affected children.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better preserve heart function and improve outcomes for children with Fontan circulation.
How similar studies have gone: Previous research has indicated that targeting oxidative stress and mitochondrial dysfunction may provide new avenues for treating heart failure, suggesting potential success for this approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Reddy, Sushma — Stanford University
- Study coordinator: Reddy, Sushma
Related research
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Lipid damage and mitochondria: new ways to protect the Fontan heart
A Stanford-led study aims to find new targets and biomarkers to preserve heart function in children with Fontan circulation by looking at how oxidative stress damages heart cell powerhouses and affects blood vessels.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.