Senescent cells in single-ventricle heart disease
Senescent Cell States in Single Ventricle Disease with Heart Failure
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11445191
The team is looking at how aged support cells in the heart may lead to heart failure in people born with a single working ventricle.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11445191 on ClinicalTrials.gov |
What this research studies
From your perspective, researchers will examine heart-support cells called fibroblasts taken from people with single-ventricle congenital heart disease and from mouse models to see how they become senescent. They will use detailed cell-level profiling and lab experiments to map cell states, signals, and energy use, and will build datasets to predict which hearts are at risk of failing. The project combines human tissue and clinical data with mouse studies to test how these cell states affect heart repair after surgery. The long-term aim is to identify specific targets that could be developed into treatments for failing single-ventricle hearts.
Who could benefit from this research
Good fit: Ideal candidates are infants, children, or adults with single-ventricle congenital heart disease who can provide surgical tissue samples, clinical data, or consent to follow-up.
Not a fit: People without single-ventricle congenital heart disease, or those unable to provide tissue samples or clinical follow-up, would be unlikely to directly benefit from this project.
Why it matters
Potential benefit: If successful, this work could point to treatments that prevent or reverse heart failure in people with single-ventricle congenital heart disease.
How similar studies have performed: Work targeting senescent cells has shown promise in other types of heart disease in preclinical and early clinical work, but applying these approaches to single-ventricle congenital heart disease is largely novel.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARTIN, JAMES F — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: MARTIN, JAMES F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.