Condition

Moyamoya Disease clinical trials and research

• 19Clinical trials
• 4NIH research projects
• 1New in 30 days
• 6Countries

Newest Moyamoya Disease clinical trials

All recruiting trials (19)

• Risk prediction for stroke and cognitive decline in Moyamoya disease and Moyamoya syndrome

  A large multicenter study tests whether combining clinical data, imaging, lab and genetic information can predict who will have stroke or cognitive decline among people with Moyamoya.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality and 12 other locations · NCT07894107

• 5T MRI and Metabolomics to Predict Hemorrhage Risk in Moyamoya Disease

  This study tests whether advanced 5T MRI imaging and metabolomics can help predict which moyamoya patients are at higher risk of intracranial hemorrhage.

  Recruiting Beijing Hospital · Beijing, Beijing Municipality · NCT07781579

• XR-assisted CT-guided localization for EC-IC bypass in Moyamoya and chronic cerebral ischemia

  The study tests whether a metaverse-based surgical simulation with extended reality helps localize vessels during EC-IC bypass for moyamoya disease or chronic cerebral ischemia.

  Recruiting National Taiwan University Hospital · Taipei · NCT07711457

• Family screening and early detection for moyamoya disease

  This project will try to find biological signs and 5T high-resolution MRI features that could detect moyamoya earlier in people with the disease, their first-degree relatives, and people without a family history.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07517354

• Remimazolam: target-controlled infusion versus manual infusion during cerebrovascular bypass

  This trial will test whether target-controlled infusion uses less remimazolam than manual infusion in adults undergoing cerebrovascular bypass surgery for moyamoya disease.

  Recruiting Seoul National University Hospital · Seongnam-si, Gyeonggi-do · NCT07377695

• Cardiac index–guided blood flow management during pediatric Moyamoya EDAS surgery

  This study will test whether using each child's cardiac index to guide fluids and hemodynamic care during EDAS lowers postoperative transient ischemic episodes in children with Moyamoya disease.

  Recruiting Seoul National University Hospital · Seoul · NCT07304947

• Combined cognitive and motor training for people with stroke or Moyamoya disease

  This trial will test whether combined cognitive-motor training helps people with post-stroke cognitive impairment or Moyamoya disease improve their thinking and movement.

  Recruiting National Taiwan University Hospital · Taipei · NCT07144930

• Symani Restore surgery for Moyamoya disease

  This study tests using the Symani Surgical System to assist surgeons performing neurosurgery in adults with moyamoya disease.

  Recruiting Jacobs institute · Buffalo, New York · NCT07140731

• iPSC-derived exosome treatment for Moyamoya disease

  This Phase 1 trial will test whether applying iPSC-derived extracellular vesicles to the temporal muscle can help adults with Moyamoya disease who had a temporal muscle patch but still have inadequate blood flow.

  Recruiting Phase 1 Tongji Hospital · Wuhan, Hubei · NCT07065409

• Evaluating cognitive impairment in moyamoya disease patients

  This study is trying to see how moyamoya disease affects thinking skills and whether brain surgery can help improve them.

  Recruiting Beijing Tiantan Hospital · Beijing, China · NCT06832839

• Evaluating statins for treating Moyamoya disease

  This study is testing if statin medication can help improve the condition and outcomes for people with Moyamoya disease.

  Recruiting Beijing Tiantan Hospital · Beijing, China · NCT06817434

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Using a digital twin app to support people in secondary prevention after stroke, Moyamoya disease, or cerebral amyloid angiopathy

  This trial will try the STRATIF-AI app plus usual secondary prevention care to see if it improves daily self-care and the patient experience for adults after stroke, Moyamoya disease, or CAA.

  Recruiting Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Milan, Michigan · NCT06714097

• Improving imaging techniques for Moyamoya Disease

  This study is testing new imaging techniques to see if they can improve care for people with Moyamoya Disease by better understanding how blood flow changes over time.

  Recruiting University Hospital Tuebingen · Tübingen, Baden-Wurttemberg · NCT06330818

• Observing brain networks in moyamoya disease patients under anesthesia

  This study looks at how brain blood flow and activity change in patients with moyamoya disease while they are under anesthesia to help improve their care during surgery.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06041659

• Registry of brain-heart comorbidity in China

  This study is trying to build a big database to better understand and manage the connection between brain and heart problems in people across China.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality and 13 other locations · NCT05961748

• Understanding the progression and prognosis of Moyamoya disease

  This study is trying to see how Moyamoya disease affects brain images and thinking skills over time to help improve diagnosis and treatment for patients.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT05619068

• Long-term outcomes of conservative management in moyamoya disease patients and their relatives

  This study looks at how well non-surgical treatments work for people with moyamoya disease and their family members over time.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT05332756

• Registry for patients with rare diseases

  This study is creating a central registry for people with rare diseases to help connect them with researchers and improve treatments.

  Recruiting Sanford Health · Sioux Falls, South Dakota · NCT01793168

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• RNF213 and Moyamoya Disease in Children

  A study in young children will explore how the RNF213 gene affects blood vessel cells and contributes to Moyamoya disease, with the aim of finding new ways to prevent or treat strokes.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11356605

• Personalized vascular and metabolic signs after revascularization in moyamoya disease

  A multi-site study will look at brain imaging and blood/CSF signals in adults with moyamoya disease to understand which biomarkers relate to stroke risk and how patients respond to treatment.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11327640

• Understanding how blood flow and brain health relate to treatment in moyamoya disease

  This study is looking at how blood flow and certain markers can help us understand the risk of strokes in people with moyamoya disease, so we can better identify who might benefit from surgery to improve their condition.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11074611

• Investigating the role of a gene in the development of Moyamoya disease

  This study is looking at how a specific gene called SETD5 affects Moyamoya disease, which causes blood vessels in the brain to narrow and can lead to strokes, especially in kids, with the goal of finding new ways to help improve treatment for patients.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10724796

Related topics

Quick answers

How many Moyamoya Disease clinical trials are recruiting right now?

19, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in China (10 trials), South Korea (2 trials), United States (2 trials), Taiwan (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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