P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetic, behavior, and vascular data
Official title: P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India
Funded at Emory University · NIH-11604418 · Data updated 2026-11-12
Aims to predict Alzheimer’s disease risk in middle-aged South Asians by combining genetic, lifestyle, and vascular information to catch early changes before dementia develops.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $106,846 |
| NIH project number | 3R01AG089759-03S3 |
| Project ID | NIH-11604418 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older, especially those of South Asian ancestry, who are part of or similar to the Precision-CARRS cohort and through collaboration with Emory University.
✕Less likely to help
Individuals not represented in the cohort or who do not share the studied risk profiles may not benefit from this research.
What this research studies
This project uses a large South Asian cohort to build and test models that integrate genetic data with behavioral and vascular factors to identify early signs of Alzheimer’s disease and related dementias. By analyzing long-term, detailed measurements from tens of thousands of participants, researchers hope to uncover modifiable risk factors and characterize different preclinical stages. The work will include genotyping and multimodal data analysis to create a machine learning framework that can predict who is at higher risk over time. If successful, the approach could support earlier detection and targeted prevention efforts for people at risk.
Why it matters
Potential benefit: If proven effective, the model could enable earlier identification of individuals at risk and inform personalized prevention strategies to delay or reduce progression to Alzheimer’s dementia.
How similar studies have gone: Similar multimodal approaches have shown promise in risk stratification for neurodegenerative diseases, though this specific population and data integration approach are novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
Related research
Other NIH-funded projects on the same topics.
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P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data
Aimed at people 21 and older, this project looks at how biology, behavior, and blood vessel health together may signal the early risk of Alzheimer’s disease and related dementias in South Asians.
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Sex-specific blood biomarkers predict dementia risk in older adults
This NIH project tests how blood biomarkers and sex differences predict future dementia in older people, with the goal of personalized prognosis and prevention.
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How sleep and body temperature affect Alzheimer's risk in adults with Down syndrome
Researchers will follow adults with Down syndrome over several years to learn whether sleep problems and lower body temperature are linked to earlier Alzheimer's changes.
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Sleep and body temperature changes linked to Alzheimer’s risk in adults with Down syndrome
This project looks at whether sleep problems and lower body temperature in adults with Down syndrome are linked to higher chances of developing Alzheimer’s disease.
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Sex-specific blood biomarkers to predict Alzheimer's and related dementias
This project aims to use blood biomarkers to predict risk of Alzheimer's-related conditions in older adults, with attention to how sex differences may change risk.
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How blood tests and risk factors differ by sex for Alzheimer's and related dementias
This project looks at blood tests (amyloid, tau, and neurodegeneration markers) and other risk factors in older men and women to help spot who may develop Alzheimer's or related dementias.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.