Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Official title: The role of neuronal hyperexcitability and proteostasis in Alzheimer's disease
Funded at Nathan S. Kline Institute for Psych Res · NIH-11627965 · Data updated 2026-11-12
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nathan S. Kline Institute for Psych Res NIH-funded |
| Lab location | 1 site (Orangeburg, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $779,427 |
| NIH project number | 7RF1AG087504-03 |
| Project ID | NIH-11627965 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with or at risk for Alzheimer’s disease who could participate in future translational research or clinical trials.
✕Less likely to help
This work is in animals; direct benefits to patients are not guaranteed, but insights may inform human studies.
What this research studies
This project uses a mouse model that mimics Alzheimer’s pathology to explore how abnormal brain activity and problems with protein recycling contribute to disease progression from early brain areas to memory regions. By studying the locus coeruleus and related networks, the team aims to map how hyperexcitability and proteostasis dysfunction may push the pathology toward the hippocampus and cortex. The findings could identify moments when interventions targeting brain activity or protein clearance might slow or alter disease trajectory. The work combines neuroscience and cellular biology to connect electrical activity with cellular cleanup pathways in Alzheimer’s.
Why it matters
Potential benefit: If successful, this work could highlight new targets to slow or modify Alzheimer’s progression and inform future human studies or therapies.
How similar studies have gone: Previous research suggests brain activity and proteostasis are linked to Alzheimer’s pathology in animal models, supporting potential translational relevance.
Where this research is happening
-
Nathan S. Kline Institute for Psych Res
Orangeburg, United States Active
Researchers
- Principal investigator: Hussaini, Abid — Nathan S. Kline Institute for Psych Res
- Study coordinator: Hussaini, Abid
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.