Lipids and brain aging in Alzheimer's disease
Official title: Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11606401 · Data updated 2026-11-12
Aims to understand how lipids in the body relate to aging of the brain and Alzheimer's disease by studying blood and brain-related lipid patterns.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $75,599 |
| NIH project number | 3R01AG081322-05S2 |
| Project ID | NIH-11606401 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals at risk for or living with Alzheimer's disease or related dementias, and those contributing biological samples or data.
✕Less likely to help
People without Alzheimer's or related dementias may not directly benefit from this research.
What this research studies
This project uses large lipidomics datasets and advanced analytics to map how lipid turnover changes across aging and in Alzheimer's disease. By integrating data from multiple cohorts and applying machine learning, it seeks to identify lipid-related markers and pathways that mirror disease progression. The goal is to build a detailed molecular atlas of AD, linking peripheral lipid changes to brain biology to inform future therapies.
Why it matters
Potential benefit: If successful, this work could point to new lipid-based biomarkers and drug targets that help diagnose or slow Alzheimer's-related brain aging.
How similar studies have gone: Prior work in AD metabolomics and lipidomics has generated informative molecular maps and potential targets, with ongoing replication in diverse cohorts.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Kaddurah-Daouk, Rima F — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Kaddurah-Daouk, Rima F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.