P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data
Official title: P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India
Funded at Emory University · NIH-11604417 · Data updated 2026-11-12
Aimed at people 21 and older, this project looks at how biology, behavior, and blood vessel health together may signal the early risk of Alzheimer’s disease and related dementias in South Asians.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,148,090 |
| NIH project number | 3R01AG089759-03S2 |
| Project ID | NIH-11604417 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older, especially individuals of South Asian descent, who may be at risk for Alzheimer’s disease or related dementias.
✕Less likely to help
Individuals without risk factors or those not participating in genetic or longitudinal data collection may see no direct benefit.
What this research studies
This project plans to use a large, long-term dataset from a South Asian population to study early signs and risk factors of Alzheimer’s disease before symptoms appear. Researchers will combine genetic information with socio-behavioral and vascular/metabolic data to create models that can predict who might develop Alzheimer’s or related dementias. The study builds on existing cohorts and uses machine learning to identify patterns across many types of data. Findings could lead to earlier detection and more targeted prevention strategies for at-risk individuals.
Why it matters
Potential benefit: If successful, this work could enable earlier identification of people at risk and inform personalized prevention strategies.
How similar studies have gone: Previous studies show the promise of multimodal data and machine learning for predicting neurodegenerative risk, but this project advances by focusing on a high-risk South Asian cohort.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
Related research
Other NIH-funded projects on the same topics.
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P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetic, behavior, and vascular data
Aims to predict Alzheimer’s disease risk in middle-aged South Asians by combining genetic, lifestyle, and vascular information to catch early changes before dementia develops.
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Sex-specific blood biomarkers to predict Alzheimer's and related dementias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.