Managing homocysteine levels in Parkinson's patients on levodopa

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates the levels of homocysteine in patients with Parkinson's disease who are being treated with levodopa. The study aims to determine if B vitamin therapy can effectively lower elevated homocysteine levels and assess the subsequent effects on cognitive function. Participants will receive folic acid, vitamin B6, and vitamin B12 as part of the intervention. The study focuses on understanding the relationship between homocysteine levels and cognitive health in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosis of probable Parkinson's Disease according to Movement Disorders Society criteria.
2. Currently treated with levodopa at a minimum dose of 300 mg/day
3. Montreal Cognitive Assessment (MOCA) ≥15
4. Demonstrated capacity to provide informed consent.
5. 40-90 years of age
6. Estimated glomerular filtration rate ≥60
7. Absence of uncontrolled hypertension in medical history
8. Absence of insulin use

Exclusion Criteria:

\-

Where it's running

• Oregon Health & Science University (OHSU)
  Portland, Oregon, United States Recruiting

Study contacts

• Principal investigator: Joseph Quinn, MD — Oregon Health & Science University (OHSU)
• Study coordinator: Madeline Armendariz Sullivan
• Email: PDResearch@ohsu.edu
• Phone: 503-501-8478

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using deep rTMS to improve memory in Alzheimer's Disease

  This study is testing if a new brain treatment called deep rTMS can help improve memory in people with mild to moderate Alzheimer's Disease.

  Recruiting Phase 1/2 University of California, Los Angeles · Los Angeles, California · NCT06597942

• Using brain stimulation to improve memory and motivation in older adults

  This study is testing if a type of brain stimulation can help improve memory and motivation in older adults, including those showing early signs of Alzheimer's disease.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06956300

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• How physical activity might help people with Parkinson’s disease who have DBS-STN implants

  This study tests whether adding regular physical activity can help people with Parkinson’s who have DBS-STN stimulation by trying a structured physiotherapy approach alongside standard care.

  Recruiting Medical University of Warsaw · Warsaw · NCT07838636

• Home-based brain stimulation plus online chair yoga for chronic knee pain in people with Alzheimer's disease

  This project will test whether combining home-based low-intensity brain stimulation (tDCS) with online chair yoga can reduce chronic knee pain in older adults with Alzheimer's disease and related dementias.

  Recruiting University of Arizona · Tucson, Arizona · NCT07303998

• Carotid artery wall viscosity and memory problems in older adults

  This project will test whether the viscous behavior of the carotid artery wall is linked to memory problems in people over 70 with memory complaints, Alzheimer's disease, or vascular dementia.

  Recruiting University Hospital, Rouen · Rouen · NCT07205003

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.