Condition

s Disease (AD) clinical trials and research

• 10Clinical trials
• 25NIH research projects
• 6Countries

Newest s Disease (AD) clinical trials

All recruiting trials (10)

• Brain PET imaging with [18F]Fluorbetazine to see amyloid plaques in people with normal thinking, MCI, or Alzheimer’s

  This study tests a PET scan using [18F]Fluorbetazine to see if it can reliably detect amyloid plaques in the brain across people with normal cognition, MCI, or Alzheimer's disease.

  Recruiting Phase 3 HTA Co., Ltd. · Beijing, Beijing Municipality · NCT07764679

• Treatments for sustained improvement in symptomatic Alzheimer’s disease (18 months)

  This trial tests whether adding atomoxetine or metformin to standard care helps people with Alzheimer’s disease or related dementia see lasting improvements over 18 months.

  Recruiting at 2 sites Phase 3 University College, London · Cambridge and 1 other locations · NCT07724132

• Multitasking strategy training to boost executive control in healthy older adults

  This trial tests whether a web-based multitasking game, with or without strategy training, helps healthy adults aged 60–75 improve their executive control.

  Recruiting Rutgers, The State University of New Jersey · Newark, New Jersey · NCT06995638

• Cervical lymphatic bypass for treating Alzheimer's disease

  This study is testing a new surgery to see if it can help people with mild to moderate Alzheimer's disease by improving the way the brain clears out harmful proteins.

  Recruiting Changi General Hospital · Singapore · NCT06965062

• Longitudinal study on cognitive health and Alzheimer's disease

  This study is testing how changes in certain brain markers relate to memory and thinking skills in people over 65 to better understand Alzheimer's disease.

  Recruiting Imperial College London · London · NCT06953167

• Using eye imaging and blood tests to detect Alzheimer's early

  This study is testing if eye scans and blood tests can help find signs of Alzheimer's disease earlier in people aged 50 and older, whether they have the disease or not.

  Recruiting Peking University First Hospital · Beijing · NCT06924359

• Screening for financial hardship in Alzheimer's and dementia patients

  This study is trying to understand the financial struggles faced by people with Alzheimer's and their caregivers to see how it affects their well-being and care choices.

  Recruiting Fred Hutchinson Cancer Center · Seattle, Washington · NCT06922188

• Identifying protein biomarkers in biofluids for neurodegenerative disorders

  This study is trying to find specific proteins in blood and other fluids that could help doctors diagnose and manage neurodegenerative diseases like Parkinson's and Alzheimer's earlier and better.

  Recruiting Neuromed IRCCS · Pozzilli, Italy · NCT06803784

• Effects of gamma light stimulation on brain activity in older adults

  This study is testing if daily gamma light stimulation can improve brain activity and thinking skills in healthy older adults aged 55 and up.

  Recruiting Chang Gung Memorial Hospital · Taoyuan, Guishan · NCT06715995

• Using deep rTMS to improve memory in Alzheimer's Disease

  This study is testing if a new brain treatment called deep rTMS can help improve memory in people with mild to moderate Alzheimer's Disease.

  Recruiting Phase 1/2 University of California, Los Angeles · Los Angeles, California · NCT06597942

NIH-funded research (25)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Alzheimer’s disease and related brain changes linked to chemicals in the body

  This NIH grant supports a patient-centered effort to map how environmental exposures and body chemistry relate to Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11609306

• Understanding how everyday exposures affect Alzheimer's disease progression

  A national research effort is studying how environmental exposures, gut health, diet, and metabolism relate to Alzheimer's and related dementias to identify new ways to diagnose and treat these conditions.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11609305

• How environment, gut health, and metabolism affect Alzheimer’s disease

  This grant looks at how environmental exposures, gut microbes, diet, and metabolism influence Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11609304

• Understanding how chemical exposures affect Alzheimer's disease progression

  This project studies how environmental chemicals and other biological factors influence brain health and the course of Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11605998

• Understanding how brain hyperexcitability and sex differences affect Alzheimer’s disease

  This grant tests whether brain hyperexcitability linked to a genetic risk (APOE4) and sex differences contribute to memory decline in Alzheimer’s disease, using computer simulations and mouse data to guide potential human treatments.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11537709

• DUET: a home VR-based program to support people with Alzheimer’s and their caregivers

  A digital VR program called DUET helps people with Alzheimer's-related dementias and their caregivers stay mentally engaged and connected at home.

  NIH research Ralphvr INC. · Lexington, United States · NIH-11408862

• CNS Exosomes and Adaptive Immunity in Alzheimer’s Disease

  This project studies how tiny brain vesicles called exosomes may activate the body's immune system in Alzheimer’s disease, with the goal of understanding mechanisms that could lead to new treatments.

  NIH research Tufts University Boston · Boston, United States · NIH-11380705

• How everyday chemical exposures may affect Alzheimer's disease and its course

  Researchers will analyze blood, gut, genetic, and brain imaging data from people with and without Alzheimer's to find chemical and metabolic patterns tied to the disease.

  NIH research Duke University · Durham, United States · NIH-11379382

• How everyday chemical exposures may change Alzheimer's and its course

  This project looks at how chemicals in the environment, diet, and the gut interact with genes and blood chemistry to relate to Alzheimer's for people with or at risk for the disease.

  NIH research Duke University · Durham, United States · NIH-11379381

• Protective Relin Variant in Alzheimer’s Preventive Research

  This NIH grant explores how a rare genetic variant may protect against Alzheimer’s disease and what this could mean for preventing dementia in people at risk.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11356906

• Can nilotinib reverse high‑fat diet–related brain changes in Alzheimer's and do males and females respond differently?

  This work looks at whether the leukemia drug nilotinib can improve brain energy, memory, and Alzheimer’s brain changes caused by a high‑fat diet, and whether effects differ for males and females.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11324282

• RNAi-based approach to modify ApoE, immune signals, and tau for a potential Alzheimer’s treatment

  A gene-silencing strategy in the brain aims to slow or alter Alzheimer’s disease by targeting ApoE, immune signals, and tau together.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11300816

• Brain overactivity and sex differences in Alzheimer's linked to APOE-ε4

  Researchers are looking at whether the anti-seizure drug levetiracetam can calm brain overactivity and help memory in people at risk for Alzheimer's because of the APOE-ε4 gene, with a focus on women.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11187233

• Chemical exposures and Alzheimer's progression

  This project looks at how everyday chemical exposures, the gut microbiome, genes, and blood metabolites relate to Alzheimer's disease in people with or at risk for dementia.

  NIH research Duke University · Durham, United States · NIH-11170671

• Smart cell delivery to target and control combination treatments for Alzheimer's

  A team is developing a living cell system to carry and release combinations of Alzheimer's medicines directly where they're needed for people with Alzheimer's disease.

  NIH research Buck Institute for Research on Aging · Novato, United States · NIH-11126840

• How tiny particles from brain cells may trigger the immune system in Alzheimer’s

  This project looks at whether small vesicles released by brain cells carry Alzheimer’s-related signals that activate the immune system in people with Alzheimer’s disease.

  NIH research Tufts University Boston · Boston, United States · NIH-11103395

• Understanding how aging affects brain function in Alzheimer's disease

  This study is looking at how the aging process affects brain health and could lead to problems like Alzheimer's disease, with the hope of finding new ways to help people with these conditions.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11098517

• Investigating how a high fat diet affects Alzheimer's disease differently in men and women and if nilotinib can help.

  This study is looking at how a high-fat diet affects Alzheimer's disease differently in men and women, and it will test if a leukemia drug called nilotinib can help improve brain health and memory in mice that are on this diet.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11061864

• New treatments for Alzheimer's Disease using protein activators

  This study is looking at new pills that could help fight Alzheimer's Disease by boosting a protein that may help reduce brain inflammation and other issues related to the condition, and it's testing how well these pills work in different models.

  NIH research Atux Iskay Group LLC · Plainsboro, United States · NIH-11041145

• Investigating the link between insulin resistance and Alzheimer's disease

  This study is looking at how problems with insulin in the brain might be linked to Alzheimer's disease and aims to find new ways to help improve thinking and memory for people dealing with this condition.

  NIH research Regene LLC · Belchertown, UNITED STATES · NIH-11014382

• Investigating how chemical exposures affect Alzheimer's disease and its progression

  This study is looking at how things like your environment, genes, diet, and lifestyle affect brain health, especially in relation to Alzheimer's disease, and it invites patients to help researchers understand how their unique body chemistry connects to their thinking and memory.

  NIH research Duke University · Durham, United States · NIH-10973577

• Exploring how brain activity differences between sexes affect Alzheimer's disease.

  This study is looking at how differences in brain activity might affect Alzheimer's disease, especially in women with a specific gene, and it’s testing whether a common seizure medication can help improve thinking skills in both people and mice.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-10932678

• A new method to deliver drugs for Alzheimer's disease treatment.

  This study is exploring a new way to deliver medications for Alzheimer's disease that could make treatments work better by targeting different aspects of the condition, so patients might have a more effective option for managing their symptoms.

  NIH research Buck Institute for Research on Aging · Novato, United States · NIH-10873903

• Developing a new organoid tool to study and treat Alzheimer's disease.

  This study is working on a special toolkit that uses tiny brain-like structures to help us learn more about Alzheimer's disease and find new treatments, which could ultimately help patients like you.

  NIH research Sxrna Technologies, INC. · Albany, United States · NIH-10765970

• Using AI to create personalized treatments for Alzheimer's Disease

  This study is working on a smart app that will help doctors create personalized treatment plans for people with Alzheimer's Disease who also have other health issues like heart problems, diabetes, or depression, by looking at how different medications affect their thinking skills.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10701069

Related topics

Quick answers

How many s Disease (AD) clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (3 trials), China (2 trials), United Kingdom (2 trials), Singapore (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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