Metabolic clues from lipids in aging and Alzheimer's disease
Official title: Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11606400 · Data updated 2026-11-12
A lipid-focused research effort is exploring how fat-related molecules influence brain aging and Alzheimer's disease to uncover new ideas for care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $75,599 |
| NIH project number | 3R01AG081322-05S1 |
| Project ID | NIH-11606400 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals at risk for or living with Alzheimer’s disease or related dementias, or those contributing to AD biomarker studies.
✕Less likely to help
People without Alzheimer’s disease or related dementias may not directly benefit from this specific biomarker-oriented research.
What this research studies
This project studies how lipid metabolism changes with aging and in Alzheimer’s disease by analyzing large lipid and metabolite datasets from diverse cohorts. It integrates metabolomics, lipidomics, informatics, and machine learning to map metabolic changes onto disease pathways. The work builds a comprehensive molecular atlas for AD to illuminate mechanisms and potential drug targets. Results aim to reveal why some individuals differ in disease progression and response to therapies. The team collaborates across centers to share data openly and ensure rigorous, reproducible science that could guide future treatments.
Why it matters
Potential benefit: If successful, the research could identify new lipid-based biomarkers and targets to slow or alter brain aging and Alzheimer's progression.
How similar studies have gone: Previous AD metabolomics efforts have defined metabolic changes and generated a molecular atlas, supporting potential translational value.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Kaddurah-Daouk, Rima F — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Kaddurah-Daouk, Rima F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.