Condition

Renal Cancer clinical trials and research

• 39Clinical trials
• 15NIH research projects
• 21Countries

Newest Renal Cancer clinical trials

All recruiting trials (39)

• Irreversible Electroporation for Recurrent Pelvic Tumors

  This study tests whether using irreversible electroporation (IRE) is safe and helps control recurrent pelvic tumors in adults who can’t have other local treatments.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT07782164

• Registry of Minimally Invasive Cancer Treatments Using Spectral Angio-CT Guidance

  This registry collects data from adults undergoing image-guided, minimally invasive cancer treatments to see if spectral angio-CT guidance helps predict outcomes and improve planning.

  Recruiting Leiden University Medical Center · Lyon, Auvergne-Rhône-Alpes and 2 other locations · NCT07636148

• Hospital admissions for blood in the urine

  This international observational project will look at how hospitals manage adults admitted with blood in the urine to see which approaches lead to shorter stays and better outcomes.

  Recruiting British Urology Researchers in Surgical Training · London · NCT07395037

• SL-28 for Advanced Solid Tumours

  A new allogeneic cell therapy called SL-28 is being tested in adults with advanced solid tumors to see if it is safe and can help shrink tumors.

  Recruiting Phase 1/2 Second Life Therapeutics · Sydney, New South Wales and 2 other locations · NCT07341737

• Spectral CT during embolization and ablation for liver and kidney tumors

  This pilot tries a new spectral CT technique during image-guided embolization and ablation for adults with liver or kidney tumors to see if it improves image quality and helps guide treatment.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT07303725

• Image-guided stereotactic body radiotherapy for primary kidney cancer (STONE)

  This will try high-dose, focused radiation (SBRT) to treat adults with a single small primary kidney cancer who are not good candidates for surgery or who decline surgery.

  Recruiting Istituto Clinico Humanitas · Milan, Milan and 1 other locations · NCT07299357

• Stereotactic Body Radiotherapy with Continuous Tracking for Kidney Tumors

  This trial tests a precise, high-dose SBRT approach to treat primary or secondary kidney tumors in adults using robotic tracking to see if it reduces kidney and treatment-related side effects.

  Recruiting IRCCS San Raffaele · Milan, Milano (MI) · NCT07285538

• PF-08634404 alone and with other anticancer medicines for adults with advanced kidney cancer.

  This tests whether PF-08634404, given alone or with other cancer medicines, is safe and helps adults with locally advanced or metastatic kidney cancer who have not had prior systemic treatment.

  Recruiting at 157 sites Phase 1/2 Pfizer · Phoenix, Arizona and 182 other locations · NCT07227415

• Off-clamp, sutureless robot-assisted partial nephrectomy for small kidney tumors

  This will try a robot-assisted partial nephrectomy that avoids artery clamping and sutures to better preserve kidney function in adults with renal tumors up to 7 cm.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07141225

• Work status and return to work after treatment for bladder, prostate, and kidney cancers and urinary stones

  This project will test how treatment for bladder, prostate, or kidney cancer and procedures for urinary stones affect whether adult patients can return to work and their quality of life.

  Recruiting Jagiellonian University · Krakow, Malopolska · NCT07088536

• Do women over 50 with sudden bladder infection symptoms and visible blood in their urine need full cancer checks?

  This project will see if women 50 and older who have sudden visible blood in their urine with short-term bladder infection symptoms can safely avoid full cancer investigations.

  Recruiting Vastra Gotaland Region · Uddevalla · NCT07037589

• Detecting double-positive (tumor marker/CD45+) cells in the blood of people with metastatic cancer

  This one-day study will test two blood-based methods to find double-positive tumor/CD45+ circulating cells in adults who are about to start treatment for various metastatic cancers.

  Recruiting Institut Claudius Regaud · Toulouse · NCT06967961

• BL-B01D1 plus a TKI, with or without pembrolizumab, for advanced kidney cancer

  This trial will test whether adding the experimental drug BL-B01D1 to a standard TKI—with or without the immunotherapy pembrolizumab—helps people with locally advanced or metastatic kidney cancer.

  Recruiting Phase 2 Sichuan Baili Pharmaceutical Co., Ltd. · Shanghai, Shanghai Municipality · NCT06962787

• Using advanced CT scans to monitor treatment in kidney cancer patients

  This study tests if advanced CT scans can help track how well treatments are working for people with metastatic kidney cancer who are receiving new combination therapies.

  Recruiting at 2 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, BO and 1 other locations · NCT06863857

• ImmunoPET imaging for detecting malignant cancers

  This study is testing a new imaging method to see if it can better detect certain types of cancer in patients who have or might have these diseases.

  Recruiting Phase 2 RenJi Hospital · Shanghai · NCT06852638

• Comparing pain management methods for kidney surgery

  This study is testing which pain management method, either an epidural or an intrathecal opioid, works better for people having kidney surgery to help them recover more comfortably.

  Recruiting Phase 1 University Hospital of Split · Split · NCT06595329

• Using a digital tool to improve kidney surgery planning

  This study is testing a new digital tool to see if it helps doctors plan kidney surgery better for patients with localized kidney cancer compared to just using regular CT scans.

  Recruiting at 5 sites University Hospital, Ghent · Aalst and 4 other locations · NCT06536439

• Mobile health outreach for men's cancer screening

  This study is testing a mobile health service that brings cancer screening directly to men at their workplaces, especially those in high-risk groups, to help them get checked for prostate cancer and other urological issues.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT06357416

• Comparing spinal morphine and intravenous lidocaine for pain management in robotic kidney surgery

  This study is testing if using spinal morphine for pain relief helps people recover better after robotic kidney surgery compared to using intravenous lidocaine.

  Recruiting at 2 sites Phase 3 University Hospital, Linkoeping · Kalmar and 2 other locations · NCT06349668

• Testing MDX2001 for advanced solid tumors

  This study is testing a new drug called MDX2001 to see if it can safely help people with advanced solid tumors like breast or colon cancer.

  Recruiting at 6 sites Phase 1/2 ModeX Therapeutics, An OPKO Health Company · Denver, Colorado and 5 other locations · NCT06239194

• Observing the effects of kidney cancer surgery on patients

  This study looks at how kidney cancer surgery affects patients over time to see how it impacts their quality of life and chances of relapse.

  Recruiting IRCCS San Raffaele · Milan, MI · NCT06147349

• Combining Pembrolizumab and Axitinib for Kidney Cancer with Tumor Thrombus

  This study is testing whether combining two medications, Pembrolizumab and Axitinib, can help shrink kidney cancer tumors that have spread to a major vein before surgery.

  Recruiting at 3 sites Phase 2 University of Colorado, Denver · Aurora, Colorado and 2 other locations · NCT05969496

• Using a radiotracer to detect granzyme B in advanced cancers

  This study is testing a new imaging tool to see if it can help find specific markers in advanced cancers, especially in patients with kidney and prostate cancer, to better understand how their tumors respond to treatment.

  Recruiting Phase 1/2 University of California, San Francisco · San Francisco, California · NCT05888532

• 3D image-guided robot-assisted surgery for complex kidney tumors

  This study is testing a new robot-assisted surgery technique for complex kidney tumors to see if it leads to fewer complications and better long-term kidney function compared to the standard method.

  Recruiting at 2 sites University Hospital, Grenoble · Grenoble and 1 other locations · NCT05572216

• A decision aid for patients with kidney tumors

  This study is testing a new online tool to help patients with kidney tumors make better treatment choices based on what matters most to them.

  Recruiting NYU Langone Health · New York, New York · NCT05387863

• Validation of a blood test for early cancer detection and monitoring

  This study is testing a blood test to see if it can help find different types of cancer early and monitor patients after treatment.

  Recruiting at 3 sites Adela, Inc · Duarte, California and 16 other locations · NCT05366881

• Nationwide cohort for renal cell carcinoma data collection

  This study is collecting real-life health information from people with kidney cancer in the Netherlands to help improve treatments and understand their experiences better.

  Recruiting at 27 sites PROspective Renal Cancer Cohort Foundation · Amsterdam, North Holland and 26 other locations · NCT05326620

• Detecting renal cancer using liquid biopsy techniques

  This study is testing if changes in certain substances in blood and urine can help tell the difference between kidney cancer and non-cancerous kidney growths in patients who might have renal tumors.

  Recruiting Zealand University Hospital · Roskilde · NCT05060783

• Evaluating 68Ga-PSMA PET for advanced renal cancer diagnosis

  This study is testing if a special imaging technique called 68Ga-PSMA PET can better find advanced kidney cancer spots compared to regular CT scans and see if it helps doctors make better treatment choices for patients.

  Recruiting at 9 sites Xijing Hospital · Lanzhou, Gansu and 8 other locations · NCT04987086

• Using telemonitoring to manage side effects in cancer patients receiving immunotherapy

  This study is testing if a telemonitoring system can help cancer patients receiving immunotherapy for melanoma, lung cancer, or renal cancer manage their side effects better by reporting their symptoms regularly.

  Recruiting at 3 sites Hospices Civils de Lyon · Bron and 9 other locations · NCT04605146

• Using stereotactic body radiotherapy for patients with rare oligometastatic cancers

  This study is testing if adding a special type of targeted radiation therapy to standard treatment can help people with rare cancers that have spread to a few places live longer and feel better.

  Recruiting at 13 sites European Organisation for Research and Treatment of Cancer - EORTC · Anderlecht and 12 other locations · NCT04498767

• Using MRI to guide radiation therapy for various cancers

  This study is testing if using MRI scans to adjust radiation therapy can help people with different types of cancer, like pancreatic and lung cancer, feel better and control their tumors more effectively.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT04115254

• Evaluating progastrin levels in cancer patients

  This study is testing if measuring progastrin levels in the blood can help predict how cancer will progress and respond to treatment in patients with different types of cancer.

  Recruiting at 17 sites Hospices Civils de Lyon · Bron and 16 other locations · NCT03787056

• Infusion of checkpoint inhibitors and chemotherapy for advanced solid tumors

  This study is testing if giving a mix of immune therapy and chemotherapy directly to tumors helps people with advanced cancers feel better compared to the usual way of giving these treatments.

  Recruiting Phase 2/3 Second Affiliated Hospital of Guangzhou Medical University · Guanzhou, Guangdong · NCT03755739

• Treatment of advanced solid tumors with APL-101 for specific genetic mutations

  This study is testing a new oral medication called APL-101 to see if it helps people with advanced lung cancer and other solid tumors that have certain genetic changes, especially those who haven't had success with standard treatments.

  Recruiting at 32 sites Phase 2 Apollomics Inc. · Los Angeles, California and 34 other locations · NCT03175224

• Registry for kidney cancer DNA and family history

  This study is collecting DNA samples and health information from people with kidney cancer and their families to better understand the disease and find ways to improve prevention and treatment.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT02087852

• Collecting and storing samples from children and adults with common childhood cancers

  This study is collecting and storing samples from children and adults with common childhood cancers to help researchers learn more about these diseases and find better treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 4 other locations · NCT01109394

• Understanding genetic causes of lymphoproliferative disorders in families

  This study is trying to find out how genetics play a role in lymphoproliferative disorders, like Hodgkin's disease and lymphoma, by looking at families with a history of these cancers.

  Recruiting at 6 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 5 other locations · NCT00582621

• Collection of blood and tissue samples from patients with suspected or confirmed cancer

  This study is collecting blood and tissue samples from patients with suspected or confirmed cancer to help researchers learn more about how these cancers develop and find new treatment options.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00026884

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Profilin as a Target to Normalize Tumor Vessels in Kidney Cancer

  A new approach aims to curb blood vessel growth in a common kidney cancer by targeting a protein called Profilin 1 to improve how blood vessels form in tumors.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11640331

• Overcoming obesity-related resistance to immunotherapy in kidney cancer

  A study aims to understand why obesity affects how well immunotherapy works for people with advanced kidney cancer and how to improve treatments for those patients.

  NIH research University of Kentucky · Lexington, United States · NIH-11528804

• Copper-driven metabolism in clear cell kidney cancer relapse

  This grant studies how copper metabolism affects the growth and relapse of clear cell renal cell carcinoma to identify new ways to help patients after surgery.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11395519

• New VHL tumor-suppressor signaling in kidney cancer

  This project looks at why a common kidney cancer (ccRCC) resists treatment and how changes in a gene called VHL and a chemical tag on RNA might open new ways to fight it.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11380777

• Targeting epigenetic drivers in clear cell kidney cancer

  A doctor-scientist at Johns Hopkins is exploring how epigenetic changes shape kidney cancer and whether new therapies can target these changes.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11282705

• Targeting profilin to normalize blood vessels in kidney cancer

  This work tests whether blocking a protein called profilin can normalize tumor blood vessels and help people with clear cell kidney cancer.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11178700

• Copper and kidney cancer progression

  Researchers are looking at whether copper changes how clear cell kidney cancer cells make energy and helps tumors grow or come back.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11164829

• How loss of the VHL protein drives kidney cancer

  This work looks at how losing the VHL protein changes RNA signals in clear cell kidney cancer to find new treatment targets for patients.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11163345

• Using advanced MRI techniques to improve management of renal cancer and kidney function

  This study is looking at new MRI techniques to help doctors understand how kidney cancer affects kidney function and to see how surgery might help, so patients can get better care before and after their treatment.

  NIH research New York University School of Medicine · New York, United States · NIH-11078806

• Understanding how obesity affects cancer treatment response in kidney cancer

  This study is looking at how being overweight might affect how well immunotherapy works for people with advanced kidney cancer, and it aims to help understand when extra weight could make treatment better or worse.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11046641

• Understanding how oxygen affects kidney cancer metabolism

  This study is looking at how oxygen levels affect kidney cancer cells by creating a special sensor that can measure oxygen in living cells, which could help develop better treatments for patients like you.

  NIH research Scintillon Institute for Photobiology · San Diego, United States · NIH-11036270

• Investigating how VHL tumor suppressor affects kidney cancer

  This study is looking at a type of kidney cancer called clear cell renal cell carcinoma and how a specific gene, VHL, affects cancer cells, with the hope of finding new ways to treat patients who have this challenging condition.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10997272

• Targeting Profilin to Improve Blood Vessel Function in Kidney Cancer

  This study is looking at a protein called Profilin1 to see how it influences kidney cancer and its blood vessels, with the hope of finding new ways to improve treatments for patients like you.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10949012

• A new treatment using engineered IL-21 to target tumors in kidney cancer

  This study is testing a new treatment that uses a special version of a protein called IL-21 to help boost the immune system's fight against clear cell kidney cancer, aiming to make it safer and more effective for patients dealing with this tough form of cancer.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-10947782

• Investigating how copper affects kidney cancer progression

  This study is looking at how copper buildup in kidney cancer cells affects their growth and survival after surgery, with the hope of finding new ways to treat clear cell renal cell carcinoma and prevent it from coming back.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-10932291

Related topics

Quick answers

How many Renal Cancer clinical trials are recruiting right now?

39, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (13 trials), France (7 trials), Italy (6 trials), China (6 trials), United Kingdom (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 4, Phase 3: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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