Registry for kidney cancer DNA and family history

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This registry aims to collect DNA samples and questionnaires from individuals diagnosed with kidney cancer, their family members, and healthy controls to enhance understanding of the disease. Participants will provide saliva samples for genetic analysis, complete a Kidney Cancer Questionnaire, and share family health histories. The data collected will help in developing improved methods for preventing, diagnosing, and treating renal cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Kidney Cancer Case Cohort:

* Must be ≥ 18 years of age AND
* Must be an English-speaker AND
* Must have a diagnosis or suspicion of kidney cancer

Family Member Cohort:

* Must be ≥ 18 years of age AND
* Must be an English-speaker AND
* Must be a blood relative of the proband. Family members of probands including mother, father, sisters, brothers, half-sisters, half-brothers, daughters, sons, grandmothers, grandfathers, as well as aunts and uncles are eligible. These individuals need not have kidney cancer, as they will be used for segregation analysis of suspected variants found in the proband; requesting DNA from relatives is required.

Control Cohort:

* Must be ≥ 18 years of age AND
* Must be an English-speaker AND
* Must not have a personal history of cancer, with the exception of nonmelanoma skin cancer, AND
* Must not be a blood relative of any cases or controls enrolled in this study

Exclusion Criteria:

* Patients who, in the opinion of the primary MSKCC clinician or the investigator, have a condition that precludes their ability to provide an informed consent

Where it's running

• Memorial Sloan Kettering at Basking Ridge (Consent and Follow-up)
  Basking Ridge, New Jersey, United States Recruiting
• Memorial Sloan Kettering Monmouth (Consent and Follow up)
  Middletown, New Jersey, United States Recruiting
• Memorial Sloan Kettering Bergen (Consent and Follow up )
  Montvale, New Jersey, United States Recruiting
• Memorial Sloan Kettering Commack (Consent and Follow-up)
  Commack, New York, United States Recruiting
• Memorial Sloan Kettering Westchester (Consent and Follow up)
  Harrison, New York, United States Recruiting
• Memorial Sloan Kettering Cancer Center (All Protocol Activities)
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Jonathan Jonathan, MD — Memorial Sloan Kettering Cancer Center
• Study coordinator: Jonathan Coleman, MD
• Phone: 646-422-4432

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Irreversible Electroporation for Recurrent Pelvic Tumors

  This study tests whether using irreversible electroporation (IRE) is safe and helps control recurrent pelvic tumors in adults who can’t have other local treatments.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT07782164

• Registry of Minimally Invasive Cancer Treatments Using Spectral Angio-CT Guidance

  This registry collects data from adults undergoing image-guided, minimally invasive cancer treatments to see if spectral angio-CT guidance helps predict outcomes and improve planning.

  Recruiting Leiden University Medical Center · Lyon, Auvergne-Rhône-Alpes and 2 other locations · NCT07636148

• Hospital admissions for blood in the urine

  This international observational project will look at how hospitals manage adults admitted with blood in the urine to see which approaches lead to shorter stays and better outcomes.

  Recruiting British Urology Researchers in Surgical Training · London · NCT07395037

• SL-28 for Advanced Solid Tumours

  A new allogeneic cell therapy called SL-28 is being tested in adults with advanced solid tumors to see if it is safe and can help shrink tumors.

  Recruiting Phase 1/2 Second Life Therapeutics · Sydney, New South Wales and 2 other locations · NCT07341737

• Spectral CT during embolization and ablation for liver and kidney tumors

  This pilot tries a new spectral CT technique during image-guided embolization and ablation for adults with liver or kidney tumors to see if it improves image quality and helps guide treatment.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT07303725

• Image-guided stereotactic body radiotherapy for primary kidney cancer (STONE)

  This will try high-dose, focused radiation (SBRT) to treat adults with a single small primary kidney cancer who are not good candidates for surgery or who decline surgery.

  Recruiting Istituto Clinico Humanitas · Milan, Milan and 1 other locations · NCT07299357

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.