Investigating how copper affects kidney cancer progression
Metabolic effects of cooper in renal cancer
This study is looking at how copper buildup in kidney cancer cells affects their growth and survival after surgery, with the hope of finding new ways to treat clear cell renal cell carcinoma and prevent it from coming back.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10932291 on NIH RePORTER |
What this research studies
This research focuses on clear cell renal cell carcinoma (ccRCC), a common and aggressive type of kidney cancer. It aims to understand how copper accumulation in cancer cells influences their growth and survival, particularly after surgical treatment. By examining tissue samples from patients and using cell line models, the study will explore the metabolic changes driven by copper and how these changes may lead to cancer relapse. The findings could provide insights into new therapeutic strategies targeting copper metabolism in ccRCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with clear cell renal cell carcinoma who are undergoing or have undergone surgical treatment.
Not a fit: Patients with other types of kidney cancer or those who have not been diagnosed with ccRCC may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent relapse in kidney cancer patients by targeting copper metabolism.
How similar studies have performed: Previous research has shown that targeting metabolic pathways in cancer can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Czyzyk-Krzeska, Maria F — University of Cincinnati
- Study coordinator: Czyzyk-Krzeska, Maria F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.