NIH-funded research R01 grant

Using advanced MRI techniques to improve management of renal cancer and kidney function

Official title: Advanced Diffusion Imaging for Management of Renal Cancer: Oncologic Control and Renal Functional Reserve - Resubmission - 1

Funded at New York University School of Medicine · NIH-11078806 · Data updated 2026-11-12

This study is looking at new MRI techniques to help doctors understand how kidney cancer affects kidney function and to see how surgery might help, so patients can get better care before and after their treatment.

More Renal Cancer research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNew York University School of Medicine
NIH-funded
Lab location1 site (New York, United States)
Project startAugust 1, 2020
Project endApril 30, 2026
Funding year2025
Award (this year)$534,967
NIH project number5R01CA245671-06
Project IDNIH-11078806 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are patients diagnosed with renal cancer who are scheduled for surgical intervention.

Less likely to help

Patients with renal cancer who are not candidates for surgery or those with advanced kidney disease may not benefit from this research.

What this research studies

This research focuses on developing advanced diffusion-weighted MRI techniques to monitor renal function in patients with renal cancer. It aims to noninvasively assess the aggressiveness of tumors and predict the impact of surgical interventions on kidney function. By utilizing innovative imaging methods, the study seeks to provide better insights into the health of the kidneys before and after surgery, potentially improving patient outcomes. Patients will undergo MRI scans to evaluate their condition and track changes over time.

Why it matters

Potential benefit: If successful, this research could lead to improved management strategies for renal cancer patients, helping to preserve kidney function and reduce the risk of chronic kidney disease.

How similar studies have gone: Previous research has shown promise in using advanced MRI techniques for cancer assessment, indicating potential success for this novel approach.

Where this research is happening

  • New York University School of Medicine
    New York, United States
    Active

Researchers

  • Principal investigator: Sigmund, Eric Edward — New York University School of Medicine
  • Study coordinator: Sigmund, Eric Edward

Related research

Other NIH-funded projects on the same topics.

  • Profilin as a Target to Normalize Tumor Vessels in Kidney Cancer

    A new approach aims to curb blood vessel growth in a common kidney cancer by targeting a protein called Profilin 1 to improve how blood vessels form in tumors.

    NIH research University of Texas Dallas · Richardson, United States · NIH-11640331

  • Overcoming obesity-related resistance to immunotherapy in kidney cancer

    A study aims to understand why obesity affects how well immunotherapy works for people with advanced kidney cancer and how to improve treatments for those patients.

    NIH research University of Kentucky · Lexington, United States · NIH-11528804

  • Copper-driven metabolism in clear cell kidney cancer relapse

    This grant studies how copper metabolism affects the growth and relapse of clear cell renal cell carcinoma to identify new ways to help patients after surgery.

    NIH research University of Cincinnati · Cincinnati, United States · NIH-11395519

  • New VHL tumor-suppressor signaling in kidney cancer

    This project looks at why a common kidney cancer (ccRCC) resists treatment and how changes in a gene called VHL and a chemical tag on RNA might open new ways to fight it.

    NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11380777

  • Targeting epigenetic drivers in clear cell kidney cancer

    A doctor-scientist at Johns Hopkins is exploring how epigenetic changes shape kidney cancer and whether new therapies can target these changes.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-11282705

  • Targeting profilin to normalize blood vessels in kidney cancer

    This work tests whether blocking a protein called profilin can normalize tumor blood vessels and help people with clear cell kidney cancer.

    NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11178700

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.