Understanding how oxygen affects kidney cancer metabolism
Deciphering the dichotomy of oxygen metabolism in renal cancer using a novel genetically encoded oxygen biosensor
['FUNDING_R03'] · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · NIH-11036270
This study is looking at how oxygen levels affect kidney cancer cells by creating a special sensor that can measure oxygen in living cells, which could help develop better treatments for patients like you.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCINTILLON INSTITUTE FOR PHOTOBIOLOGY (nih funded) |
| Locations | 1 site (SAN DIEGO, UNITED STATES) |
| Trial ID | NIH-11036270 on ClinicalTrials.gov |
What this research studies
This research investigates the role of oxygen in renal cancer by developing a novel biosensor that can measure oxygen levels in living cells. The approach involves engineering a protein-based sensor that combines a heme-based protein with a fluorescent protein to monitor oxygen gradients. By understanding how different oxygen levels influence cancer cell behavior, the research aims to uncover new insights into kidney cancer metabolism and its treatment. Patients may benefit from advancements in targeted therapies based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with renal cancer who are interested in innovative treatment approaches.
Not a fit: Patients with non-cancerous kidney conditions or those not diagnosed with renal cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for kidney cancer by targeting oxygen metabolism.
How similar studies have performed: While the specific approach of using a genetically encoded oxygen biosensor is novel, similar studies have shown promise in understanding metabolic processes in cancer.
Where this research is happening
SAN DIEGO, UNITED STATES
- SCINTILLON INSTITUTE FOR PHOTOBIOLOGY — SAN DIEGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CRACAN, VALENTIN — SCINTILLON INSTITUTE FOR PHOTOBIOLOGY
- Study coordinator: CRACAN, VALENTIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.