Comparing pain management methods for kidney surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare two pain management techniques, epidural analgesia and intrathecal opioid analgesia, in patients undergoing open radical or partial nephrectomy for renal cancer. It is a prospective, single-center, randomized controlled trial conducted at the University Hospital of Split. The study will monitor various parameters, including acute pain levels, side effects, and the consumption of systemic analgesics during the first 72 hours post-surgery. The goal is to determine which method provides better pain relief and overall recovery outcomes for patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients over the age of 18, scheduled for an open radical or partial nephrectomy due to RCC.
* American Society of Anesthesiologists (ASA) physical status classification I-III.

Exclusion Criteria:

* Patients who refuse to participate in this study.
* Patients with BMI \> 35 kg/m2 or \< 15 kg/m2.
* Patients with renal dysfunction (eGFR \<15 or requirement of renal replacement therapy), liver dysfunction (Child-Pugh class C), and heart failure (NYHA IV).
* Patients with ASA physical status classification ≥ IV.
* Patients with contraindication for the interventions planned for in this study (allergies to anesthetic drugs used in this study, coagulation disorders, and infection at the injection site).
* Patients with chronic opioid dependence.
* Patients unable to communicate preoperatively due to severe dementia, language barrier, or neuropsychiatric disorder.
* Patients for whom it is impossible to carry out the aforementioned interventions for technical reasons.

Where it's running

• Univeristy Hospital of Split
  Split, Croatia Recruiting

Study contacts

• Principal investigator: Svjetlana Došenović, MD Phd — UH Split
• Study coordinator: Petra Bajto, MD
• Email: p.bajto@gmail.com
• Phone: +385955234851

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.