Condition

Palliative Care clinical trials and research

• 26Clinical trials
• 76NIH research projects
• 1New in 30 days
• 18Countries

Newest Palliative Care clinical trials

All recruiting trials (26)

• Prehospital end-of-life care: how professionals use a comfort care booklet in Strasbourg

  This study tests how emergency crew members in Strasbourg use a comfort care booklet when caring for patients at end of life, and what they think about it.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07895940

• Concise coaching to guide decisions for advanced cancer patients considering palliative procedures

  A coaching program delivered by lay providers will test whether it helps adults with advanced cancer make better, patient-aligned decisions about palliative surgeries or similar interventions.

  Recruiting Singapore General Hospital · Singapore · NCT07789093

• Primary Palliative Care: A Feasibility Project for Family Health Units

  This feasibility trial tests a GP training program plus a structured 12-week palliative-care visit plan to see if it can be carried out in primary care for adults with advanced illness.

  Recruiting University of Coimbra · Coimbra and 1 other locations · NCT07737899

• Relaxation and breathing techniques to help with breathlessness and tiredness in cancer patients in palliative care

  This study tests whether progressive muscle relaxation or deep breathing exercises can reduce dyspnea and fatigue and improve self-care in adults with cancer receiving palliative care.

  Recruiting at 4 sites Ankara University · Ankara, YENIMAHALLE and 3 other locations · NCT07619209

• Relief of dyspnea with high-flow nasal therapy in palliative care

  This study tests whether high-flow nasal therapy helps relieve breathlessness in adults receiving palliative care.

  Recruiting at 2 sites Tampere University Hospital · Tampere and 1 other locations · NCT07552935

• Palliative and supportive care to help people with inflammatory arthritis live well

  This project will see how palliative and supportive care could help adults with inflammatory arthritis live better throughout their illness.

  Recruiting Dorothy House Hospice · Bath, Wiltshire · NCT07491939

• Multidisciplinary palliative care pathway tailored to frailty for outpatient advanced cancer patients

  This study will test whether a structured outpatient palliative care pathway that uses patient-reported symptom scores to tailor care can reduce symptoms and improve care experience for adults with advanced cancer and frailty.

  Recruiting Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan, Lombardy · NCT07469761

• How medicalized residential care influences care plans for vulnerable palliative patients

  This study will see if living in a medicalized residential facility in Alsace changes how care plans are made for adults receiving palliative care.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07342985

• Annual Wellness Visits with or without GRACE support for older adults with complex needs

  This project will see if adding the GRACE geriatric care approach to Medicare Annual Wellness Visits helps older adults with complex needs and their caregivers stay healthier and avoid hospital visits.

  Recruiting Massachusetts General Hospital · Derby, Connecticut and 3 other locations · NCT07166861

• Testosterone injections to improve quality of life for men in best supportive care.

  This pilot will test whether giving Sustanon 250 testosterone injections every 15 days can improve quality of life for men with low testosterone who are receiving best supportive (palliative) care.

  Recruiting Early Phase 1 Jules Bordet Institute · Brussels · NCT07143279

• PEG feeding education for relatives of palliative care patients

  This project will test whether teaching relatives how to use PEG feeding before hospital discharge reduces caregiver burden and improves their quality of life.

  Recruiting Uludag University · Istanbul · NCT07078188

• A playful game to see if it lowers anxiety in palliative care patients

  A serious game called SPAMLO-3.0 is being tested to see if it helps reduce anxiety for people receiving palliative care, compared with standard care.

  Recruiting at 8 sites Centre Hospitalier de Saint-Brieuc · Dinan and 7 other locations · NCT07070869

• E-tailored pain management support for family caregivers of people with dementia using the PACE-app

  This trial tests whether the PACE-app, a web-based tool, can help family caregivers of people with dementia better manage their loved ones' chronic pain and improve caregiver confidence, communication, and well-being compared with usual care.

  Recruiting University of Iowa · Iowa City, Iowa · NCT07032350

• Promoting Palliative Care for Heart Failure Patients

  This trial tests a clinical decision tool that helps clinicians refer hospitalized heart failure patients to palliative care sooner to see if it improves care alignment with patients' goals.

  Recruiting at 2 sites Yale University · New Haven, Connecticut and 1 other locations · NCT06933875

• Pharmacist-led education about stopping non-cancer medicines for palliative cancer patients

  This project will see if a brochure and short video from a clinical pharmacist change how Romanian palliative cancer patients feel about stopping non-cancer medications.

  Recruiting Iuliu Hatieganu University of Medicine and Pharmacy · Baia Mare, Maramureş · NCT06771999

• Evaluating side effects of palliative radiotherapy in cancer patients

  This study tests how well palliative radiotherapy can help cancer patients with symptoms like pain and bleeding feel better.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06760806

• All Providers Better Communication Skills Program (ABCs)

  This program will test whether a blended online and virtual workshop training (ABCs) helps healthcare providers improve their serious-illness communication skills.

  Recruiting at 2 sites McMaster University · Hamilton, Ontario and 1 other locations · NCT06606470

• Improving palliative care for patients in intensive care units

  This study is testing whether specialized consultations can improve palliative care for patients in intensive care units and support their families.

  Recruiting at 27 sites Charite University, Berlin, Germany · Prague and 30 other locations · NCT06605079

• Better ICU palliative support for older adults and their families

  This trial will test whether a mobile app called ICUconnect helps older adults in the ICU and their family caregivers get the palliative care support they need compared with usual care.

  Recruiting at 4 sites Duke University · Birmingham, Alabama and 3 other locations · NCT06588556

• Using remote monitoring to assess symptoms in palliative care patients

  This study tests if using online check-ins and daily health tracking can help improve care for patients in palliative care and make their families feel more supported.

  Recruiting Our Lady's Hospice and Care Services · Dublin, Dublin · NCT06587321

• Using intranasal midazolam to treat anxiety in palliative care patients

  This study is testing whether a nasal spray of midazolam can help reduce anxiety in patients receiving palliative care.

  Recruiting at 4 sites Phase 2 Insel Gruppe AG, University Hospital Bern · Basel, Canton of Basel-City and 4 other locations · NCT06330584

• Understanding Patient Views on Reducing Medications in Advanced Cancer Care

  This study is trying to understand how patients with advanced cancer feel about reducing their medications to see what factors influence their thoughts on this process.

  Recruiting Nantes University Hospital · La Roche-sur-Yon and 7 other locations · NCT06193083

• Using LSD to help relieve distress in terminally ill patients

  This study is testing if LSD can help reduce pain, anxiety, and depression in people who are terminally ill and improve their overall quality of life.

  Recruiting at 4 sites Phase 2 University Hospital, Basel, Switzerland · Basel and 3 other locations · NCT05883540

• Yunzhi Essence to Improve Quality of Life in Advanced Cancer

  A 6‑month, randomized, placebo‑controlled test to see if Yunzhi Essence improves quality of life for people with advanced cancer receiving palliative care.

  Recruiting Phase 2 Chinese University of Hong Kong · Hong Kong · NCT05754801

• Supportive care model for patients with advanced lung cancer

  This study is testing a new supportive care program for people with advanced lung cancer to see if it helps them feel less stressed and more confident about managing their condition compared to standard care.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04900935

• Comparing two types of advance directive forms for ease of use

  This study is testing which of two advance directive forms is easier to use for adults who can read and write in English or Spanish, to help them better communicate their healthcare wishes.

  Recruiting Stanford University · Stanford, California · NCT02799537

NIH-funded research (newest 40 of 76)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• UNCOVER-PC: Helping people with advanced cancer and their families get better palliative care

  A project at Emory aims to find the best ways to give palliative care early to people with advanced cancer and to understand how it helps patients and their caregivers.

  NIH research Emory University · Atlanta, United States · NIH-11448339

• Digitally supported community workers helping HPB cancer patients receive early palliative care

  A pilot program uses digital tools and community health workers to bring early palliative care and support to people with HPB cancers and their caregivers.

  NIH research Loma Linda University · Loma Linda, UNITED STATES · NIH-11437782

• ICUconnect 2: helping older ICU patients and families get better palliative care

  A multi-site study will test a mobile app that helps ICU teams deliver personalized palliative care to older adults and support families.

  NIH research Duke University · Durham, United States · NIH-11419725

• Caring for Older African Americans: Training Clinicians to Provide Quality End-of-Life Care

  This grant aims to adapt and deliver a training program for clinicians so they can better understand and meet end-of-life care needs of older African American adults in both the South and North.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11399316

• Support-T: a mobile tool to help people with progressive pulmonary fibrosis and their caregivers get palliative care and planning

  A mobile app called SUPPORT-T helps people with progressive pulmonary fibrosis and their caregivers access palliative care and plan for the future.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11396964

• Palliative care support for patients getting CAR T therapy for blood cancers

  A clinician-led program designed to improve quality of life and ease the burden on patients and caregivers during and after CAR T cell therapy for blood cancers.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11385006

• Promoting palliative care for people with heart failure

  A pilot effort to help people with heart failure receive timely, goal-aligned palliative care through a clinical decision tool and targeted workflows.

  NIH research Yale University · New Haven, United States · NIH-11377660

• Strategies that make specialist palliative care more available for people with advanced heart failure

  A plan to find which ways cardiology and palliative care teams can work together to reach more people with advanced heart failure and improve end-of-life care.

  NIH research Yale University · New Haven, United States · NIH-11373086

• Making it easier to get palliative care in the hospital

  Testing an electronic health record alert that helps hospital teams find and offer palliative care to adults with serious illness.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11370586

• Sustaining at-Home Heart Failure Care for Older Adults in Rural Appalachia

  A team at West Virginia University is testing a nurse-led program to support older adults with heart failure and their families at home in rural Appalachia to reduce hospital visits and improve comfort.

  NIH research West Virginia University · Morgantown, United States · NIH-11367982

• Outpatient palliative care for older veterans

  This project compares different outpatient palliative care approaches to help older veterans with serious long-term illnesses feel better and get care that matches their goals.

  NIH research Durham VA Medical Center · Durham, United States · NIH-11365626

• Palliative care tools to support kidney-treatment choices for older adults with advanced CKD

  A palliative-care program helps people aged 75 and older with advanced kidney disease make informed dialysis choices that fit their values and quality of life.

  NIH research University of Rochester · Rochester, United States · NIH-11335691

• Using electronic health records and nudges to improve palliative care for seriously ill patients in hospitals

  A large hospital-based study tests how EHR prompts and gentle reminders can help doctors provide better palliative care for inpatients with serious illnesses like Alzheimer's disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11335654

• Targeted palliative care for people with metastatic breast cancer

  This program offers a short series of focused palliative care visits to people with metastatic breast cancer who are likely to have limited time left.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11333288

• Using community health workers to improve palliative care for African American adults with advanced cancer

  This program pairs culturally trained community health workers with palliative care teams to help African American adults with advanced cancer get better information, support, and access to end-of-life care options.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11318877

• Finding meaning and support for people caring for loved ones with advanced cancer

  This project offers a psychotherapy program to help people who care for loved ones with advanced cancer reduce existential distress and feel more supported.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11304532

• Better palliative and hospice care for people with Alzheimer's and related dementias

  This project will try offering hospice alongside usual medical care to improve end-of-life support for people with Alzheimer's and related dementias and their families.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11304497

• Better palliative care for Black and Hispanic people with Parkinson's and Lewy body dementia

  Designing culturally-tailored palliative care programs to better meet the needs of Black and Hispanic adults living with Parkinson's disease and Lewy body dementia.

  NIH research University of Rochester · Rochester, United States · NIH-11290717

• Palliative care and advance planning for children with rare diseases and their families

  This project offers a family-centered advance care planning program to help parents of young children with rare diseases address palliative care needs and make future medical decisions.

  NIH research Children's Research Institute · Washington, United States · NIH-11267966

• Using patient-reported health updates to improve palliative care for older adults with advanced cancer

  A study tests whether electronic patient-reported outcomes (ePRO) can help doctors deliver timely palliative care to older adults with advanced cancer.

  NIH research Dartmouth-Hitchcock Clinic · Lebanon, United States · NIH-11265892

• Helping cancer caregivers find meaning and support

  This study is looking at how a special type of therapy can help family caregivers of cancer patients feel better and find meaning in their caregiving, making it easier for them to handle the emotional and physical challenges they face.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11230360

• Palliative care for people living with Parkinson's disease

  Bringing palliative care into Parkinson's care for Veterans and others with PD to help manage symptoms, plan future care, and support caregivers.

  NIH research VA Eastern Colorado Health Care System · Aurora, UNITED STATES · NIH-11219731

• Supporting Home Palliative Care for Heart Failure Patients and Their Families in Rural Appalachia

  This project is testing a new way to provide comforting care at home for older adults with heart failure and their family caregivers in rural Appalachian communities.

  NIH research West Virginia University · Morgantown, United States · NIH-11195149

• Improving Palliative Care for People with Advanced Heart Failure

  This project looks at how different medical centers provide palliative care to people with advanced heart failure to find the best ways to help them feel better and improve their quality of life.

  NIH research Yale University · New Haven, United States · NIH-11187114

• Improving Palliative Care for People with Heart Failure

  This project aims to help doctors offer better palliative care to people living with heart failure, focusing on comfort and quality of life.

  NIH research Yale University · New Haven, United States · NIH-11181252

• Palliative care at home for people with dementia

  A team-based home palliative care program using community health workers, nurses, and social workers to support older adults with advanced dementia and their family caregivers.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11176362

• Caring for older African American patients: training clinicians for better end-of-life care

  This program trains clinicians in Birmingham and the Bronx to have respectful, culturally aware end-of-life and palliative care conversations with older African American patients.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11175428

• Mobile support program to help older adults and families in the ICU

  This project tests a smartphone app that helps ICU clinicians, patients, and family members identify and address palliative care needs for older adults in intensive care.

  NIH research Duke University · Durham, United States · NIH-11168785

• Full spectrum hemp CBD/THC for cancer symptom relief

  This study tests whether a full-spectrum hemp product containing CBD and THC can help people with cancer reduce pain, sleep problems, and anxiety.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11162249

• Community health worker support to improve palliative and end-of-life care for African American adults with advanced cancer

  This project offers trained community health workers to help African American adults with advanced cancer access palliative and end-of-life care that matches their values and needs.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11160434

• Problem-solving support for family caregivers of people with cancer

  This project offers problem-solving therapy to family caregivers of people receiving outpatient palliative cancer care to help reduce stress and improve coping.

  NIH research Washington University · Saint Louis, United States · NIH-11140327

• Making palliative care work better for people with metastatic cancer

  This project aims to find what helps specialist palliative care give better support and quality of life for people with metastatic cancer.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11129108

• Improving palliative care for older adults with dementia who speak limited English

  This study is looking at the difficulties older adults with Alzheimer's and similar conditions who don't speak much English face when trying to get palliative care, and it aims to find ways to make communication better and improve their quality of life.

  NIH research University of Washington · Seattle, United States · NIH-11128516

• Using electronic health records and behavioral nudges to improve palliative care for patients with serious illnesses.

  This study is looking to improve palliative care for people with advanced Alzheimer's and related dementias by using health records to find those who need it most, so they can get the right support and care that matches their wishes.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11111360

• Improving end-of-life care for patients with metastatic breast cancer

  This study is looking to improve the care and support for people with metastatic breast cancer by helping them and their doctors talk better about their wishes and needs as they near the end of life, so they can get the best care possible.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11103432

• Improving kidney treatment decisions for older adults with advanced kidney disease

  This study is all about helping older adults, especially those 75 and older, understand their kidney treatment choices, like dialysis or other options, by providing support and guidance to make sure their preferences and quality of life are taken into account.

  NIH research University of Rochester · Rochester, United States · NIH-11103391

• Improving Care for Parkinson's Disease and Lewy Body Dementias with Palliative Approaches

  This project explores how specialized comfort care, called palliative care, can help people living with Parkinson's disease and Lewy Body Dementias feel better and improve their quality of life.

  NIH research University of Rochester · Rochester, United States · NIH-11092853

• Understanding how palliative care can improve surgical outcomes for older adults

  This study is looking at how palliative care can make surgery better for older adults with serious illnesses by helping them feel more comfortable and supported, so they can focus on what matters most to them during their recovery.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11092692

• Improving early palliative care for patients with advanced heart failure

  This study is looking to improve support for people with advanced heart failure, especially those from underserved communities, by training friendly helpers who can coach and guide them to enhance their quality of life.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11090339

• Improving Palliative Care for Seriously Ill Patients Through Telehealth

  This project looks at how seriously ill patients and their caregivers experience palliative care delivered through telehealth compared to in-person visits, especially for those who might not have easy access to care.

  NIH research Rand Corporation · Santa Monica, United States · NIH-11083142

Related topics

Quick answers

How many Palliative Care clinical trials are recruiting right now?

26, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (6 trials), France (4 trials), Italy (3 trials), Turkey (Türkiye) (2 trials), Switzerland (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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