Yunzhi Essence to Improve Quality of Life in Advanced Cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 2 trial tests a traditional Chinese medicine product, Yunzhi Essence, versus placebo in adults with advanced cancer. Participants are randomly assigned in a double‑blind manner for six months to assess impact on quality of life and tolerability. The study uses standardized eligibility criteria including palliative prognostic assessment and cognitive screening, and follows conventional safety monitoring protocols. The product is derived from Coriolus versicolor (Yunzhi) with an aim to bolster well‑being during palliative care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with advanced cancer according to the definition from American Cancer Society;
* According to the experience of the doctor, by using Palliative Prognostic Index (score\>4), integrated with past cases and professional knowledge judged to have life expectancy not less than six months to two years;
* Abbreviated mental test (AMT) score of 6 or above;
* Voluntarily participate in this clinical trial and sign the informed consent form (acceptance of close relatives signed informed consent on behalf of the patient);
* Refer to the national standard for Clinic terminology of traditional Chinese medical diagnosis and treatment-Part 2:Syndromes/patterns, syndrome of "damp heat spleen" and "spleen deficiency with water stop" (Fulfill 2 of the main symptoms and 2 of the secondary symptoms).

Exclusion Criteria:

* Patients with a history of allergy to traditional Chinese medicine or Yunzhi;
* Patients who required nasal feeding or difficulty swallowing;
* Patients with comatose/semi-conscious, cognitively impaired with dementia/confusion, physically too ill with extremely poor general condition, or there was a language barrier.

Where it's running

• School of Chinese Medicine
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Zhixiu Lin — Hong Kong Institute of Integrative Medicine
• Study coordinator: Cho Wing Lo
• Email: louislo@cuhk.edu.hk
• Phone: 35053476

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.