Understanding Patient Views on Reducing Medications in Advanced Cancer Care
Official title: DEprescribing: Perceptions of PAtients Living With Advanced Cancer. A Multicentre, Prospective Mixed Observational Study
Run by Nantes University Hospital · NCT06193083 · Data updated 2026-11-12
This study is trying to understand how patients with advanced cancer feel about reducing their medications to see what factors influence their thoughts on this process.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 325 (estimated) |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 8 sites (La Roche-sur-Yon and 7 other locations) |
| Status | Recruiting |
| Started | February 28, 2024 |
| Main results expected | February 28, 2025 |
| Study ends | June 4, 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT06193083 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old with locally advanced or metastatic solid cancer and a life expectancy of less than one year.
✕Probably not a fit
Patients who are minors, unable to communicate in French, or have cognitive impairments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the perceptions of patients living with advanced cancer regarding the process of deprescribing, which involves reducing unnecessary medications. By conducting semi-directed individual interviews and utilizing self-administered questionnaires, the study seeks to identify factors influencing patients' attitudes towards deprescribing. The research focuses on understanding the unique perspectives of this population to adapt existing deprescribing tools and strategies effectively. The study will also assess the psychometric properties of specific health literacy scales related to this topic.
Why it matters
Potential benefit: If successful, this study could lead to improved medication management and quality of life for patients with advanced cancer.
How similar studies have gone: While there have been initiatives in geriatrics to address polymedication, this specific focus on advanced cancer patients is relatively novel and has not been extensively studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient over 18 years of age * Locally advanced or metastatic solid cancer (i.e., palliative care as defined by the World Health Organization) * Life expectancy estimated by the physician at inclusion of less than 1 year (use of surprise question to help clinician estimate life expectancy) * Hospitalized or in consultation * With at least one PIMs (identified using STOPPfrail 2) * Patient not having expressed opposition to participating in the study after receiving information from the physician. For qualitative study patients : \- Patients who have signed an authorization for the recording of their voice during the semi-structured interview for the purpose of written transcription. Exclusion Criteria: * Minor * Major under guardianship, protected person * Patient unable to speak or write French * Patient with impaired judgment, cognitive or sensory impairment that prevents him/her from receiving informed information, answering questionnaires or participating in a study interview.
Where it's running
-
CHU de Nantes
Nantes, France Recruiting -
CHD Vendée
La Roche-sur-Yon, France Not yet recruiting -
Hospices Civils de Lyon
Lyon, France Not yet recruiting -
USP - Maison de Nicodème
Nantes, France Not yet recruiting -
Hôpital Institut CURIE
Paris, France Not yet recruiting -
Institut de Cancérologie de l'Ouest
Saint-Herblain, France Not yet recruiting
Show 2 more locations
-
CH ST Nazaire
Saint-Nazaire, France Not yet recruiting -
CHRU Tours
Tours, France Not yet recruiting
Study contacts
- Principal investigator: Adrien EVIN — Nantes University Hospital
- Study coordinator: Adrien EVIN, MCU-PH
- Email: Adrien.EVIN@chu-nantes.fr
- Phone: +33253482736
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.