Clinical trial Recruiting at 1 site Observational Ages 18 and up

Understanding Patient Views on Reducing Medications in Advanced Cancer Care

Official title: DEprescribing: Perceptions of PAtients Living With Advanced Cancer. A Multicentre, Prospective Mixed Observational Study

Run by Nantes University Hospital · NCT06193083 · Data updated 2026-11-12

This study is trying to understand how patients with advanced cancer feel about reducing their medications to see what factors influence their thoughts on this process.

More Palliative Care trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment325 (estimated)
SponsorNantes University Hospital
Academic / other
Locations8 sites (La Roche-sur-Yon and 7 other locations)
StatusRecruiting
StartedFebruary 28, 2024
Main results expectedFebruary 28, 2025
Study endsJune 4, 2027
Registry record updatedSeptember 25, 2026
Trial IDNCT06193083 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 years old with locally advanced or metastatic solid cancer and a life expectancy of less than one year.

Probably not a fit

Patients who are minors, unable to communicate in French, or have cognitive impairments may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the perceptions of patients living with advanced cancer regarding the process of deprescribing, which involves reducing unnecessary medications. By conducting semi-directed individual interviews and utilizing self-administered questionnaires, the study seeks to identify factors influencing patients' attitudes towards deprescribing. The research focuses on understanding the unique perspectives of this population to adapt existing deprescribing tools and strategies effectively. The study will also assess the psychometric properties of specific health literacy scales related to this topic.

Why it matters

Potential benefit: If successful, this study could lead to improved medication management and quality of life for patients with advanced cancer.

How similar studies have gone: While there have been initiatives in geriatrics to address polymedication, this specific focus on advanced cancer patients is relatively novel and has not been extensively studied.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient over 18 years of age
* Locally advanced or metastatic solid cancer (i.e., palliative care as defined by the World Health Organization)
* Life expectancy estimated by the physician at inclusion of less than 1 year (use of surprise question to help clinician estimate life expectancy)
* Hospitalized or in consultation
* With at least one PIMs (identified using STOPPfrail 2)
* Patient not having expressed opposition to participating in the study after receiving information from the physician.

For qualitative study patients :

\- Patients who have signed an authorization for the recording of their voice during the semi-structured interview for the purpose of written transcription.

Exclusion Criteria:

* Minor
* Major under guardianship, protected person
* Patient unable to speak or write French
* Patient with impaired judgment, cognitive or sensory impairment that prevents him/her from receiving informed information, answering questionnaires or participating in a study interview.

Where it's running

  • CHU de Nantes
    Nantes, France
    Recruiting
  • CHD Vendée
    La Roche-sur-Yon, France
    Not yet recruiting
  • Hospices Civils de Lyon
    Lyon, France
    Not yet recruiting
  • USP - Maison de Nicodème
    Nantes, France
    Not yet recruiting
  • Hôpital Institut CURIE
    Paris, France
    Not yet recruiting
  • Institut de Cancérologie de l'Ouest
    Saint-Herblain, France
    Not yet recruiting
Show 2 more locations
  • CH ST Nazaire
    Saint-Nazaire, France
    Not yet recruiting
  • CHRU Tours
    Tours, France
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.