Supportive care model for patients with advanced lung cancer
Official title: Patient-centered, Optimal Integration of Survivorship and Palliative Care
Run by Massachusetts General Hospital · NCT04900935 · Data updated 2026-11-12
This study is testing a new supportive care program for people with advanced lung cancer to see if it helps them feel less stressed and more confident about managing their condition compared to standard care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | September 29, 2023 |
| Main results expected | June 1, 2027 |
| Study ends | September 1, 2027 |
| Registry record updated | November 24, 2025 |
| Trial ID | NCT04900935 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 or older, diagnosed with metastatic NSCLC within the last six months, and currently receiving targeted therapy.
✕Probably not a fit
Patients with urgent palliative care needs, cognitive impairments, or serious mental illnesses may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to develop and evaluate the feasibility of a new supportive care model called POISE for patients with metastatic Non-small Cell Lung Cancer (NSCLC). Participants will be randomly assigned to receive either the POISE intervention, which includes four sessions with trained palliative care clinicians, or standard care. The study will assess the impact of POISE on patients' distress, confidence in managing their cancer, and understanding of their condition through surveys and interviews. Approximately 70 patients receiving targeted therapy at Massachusetts General Hospital will be involved in this research.
Why it matters
Potential benefit: If successful, this approach could significantly improve the emotional and psychological well-being of patients with advanced lung cancer.
How similar studies have gone: Other studies have shown promising results with supportive care models in cancer treatment, indicating potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 or older * MGH Cancer Center patient * Within 6 months of diagnosis of metastatic NSCLC with oncogenic driver mutation (EGFR, ALK, ROS1, RET) * Receiving targeted therapy * Ability to respond in English or Spanish Exclusion Criteria: * Cognitive impairment or serious mental illness that limits ability to provide informed consent * Need for urgent palliative care or hospice referral * Pregnant women * Prisoners
Where it's running
-
Massachusetts General Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Laura A Petrillo, MD — Massachusetts General Hospital
- Study coordinator: Laura A Petrillo, MD
- Email: lpetrillo2@mgh.harvard.edu
- Phone: (617) 724-4000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.