Hyaluronic Acid Plus PRP Injection for Knee Osteoarthritis
Official title: Effect of Adding Platelet-Rich Plasma to Hyaluronic Acid on Outcomes of Injection Therapy for Knee Osteoarthritis: A Prospective, Randomized Comparative Study
Run by Implai Sp z o.o · NCT07784907 · Data updated 2026-11-12
This study tests whether a single HA injection combined with a patient’s own PRP is better at easing knee OA pain than HA alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Implai Sp z o.o Industry-sponsored |
| Locations | 1 site (Chełm, Lublin Voivodeship) |
| Status | Recruiting |
| Started | July 20, 2026 |
| Main results expected | July 2028 |
| Study ends | July 2028 |
| Registry record updated | August 25, 2026 |
| Trial ID | NCT07784907 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with symptomatic knee OA (KL II–III) and specific pain criteria who have not had recent intra-articular injections or major knee surgery.
✕Probably not a fit
Patients with very high BMI, recent knee surgery, recent intra-articular injections, or inflammatory joint disease may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this randomized, open-label study at a single center, participants with symptomatic knee OA (KL grade II–III) receive either a single intra-articular HA+PRP injection or HA alone. Fifty adults are randomized 1:1 to compare outcomes after treatment, focusing on safety and clinical performance of the combination therapy. The approach leverages autologous PRP’s growth factors alongside HA’s lubricating effect to potentially improve pain and function. The study follows post-market practice, with careful monitoring for adverse events over the trial period.
Why it matters
Potential benefit: If successful, patients may experience greater pain relief and functional improvement from a single HA+PRP injection compared with HA alone.
How similar studies have gone: Similar approaches with PRP and HA have shown mixed results; this trial adds evidence in a post-market, real-world context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Knee osteoarthritis meeting American College of Rheumatology (ACR) criteria * Kellgren-Lawrence radiographic grade II or III * Pain intensity in the study knee NRS \>= 4 and in the contralateral knee NRS \<= 2 * Written informed consent Exclusion Criteria: * BMI \>= 40 kg/m2 * Surgery of the same or contralateral knee within the previous year * Intra-articular corticosteroid injection into the study joint within 3 months, or hyaluronic acid, platelet-rich plasma or other intra-articular injection therapy within 6 months before enrolment * Systemic corticosteroid use within 2 weeks * Systemic inflammatory or autoimmune disease with joint involvement (rheumatoid arthritis, spondyloarthropathy, systemic lupus erythematosus, etc.) * Oral corticosteroid treatment * Deep vein thrombosis * Pregnancy or breastfeeding
Where it's running
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Przychodnia Specjalistyczna Lancet
Chełm, Lublin Voivodeship, Poland Recruiting
Study contacts
- Principal investigator: Jaromir Jarecki, DSc — Przychodnia Specjalistyczna Lancet
- Study coordinator: Eliza Fiedorczuk
- Email: clinical@implai.com
- Phone: +48 58 660 44 88
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.